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    Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound 

    Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)
    Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
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    Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats 

    Pitt, William G.; Husseini, Ghaleb; Roeder, Beverly L.; Dickinson, David J.; Warden, David R.; Hartley, Jonathan M.; Jones, Peter W. (American Scientific Publishers, 2011)
    Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...
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    Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers 

    Husseini, Ghaleb; Kanan, Sofian; Al-Sayah, Mohammad (American Scientific Publishers, 2015)
    Folic acid (FA) is one of the most utilized moieties in active (ligand) drug delivery. The folate receptor is widely expressed on the surface of several cell lines and tumors; including ovarian, brain, kidney, breast, and ...
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    Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks 

    Ibrahim, Mihad; Sabouni, Rana; Husseini, Ghaleb; Karami, Abdollah; Bai, Reenu Geetha; Mukhopadhyay, Debasmita (American Scientific Publishers, 2020)
    Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF ...
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    DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study 

    Husseini, Ghaleb; El-Fayoumi, Refaat I.; O'Neill, Kim L.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2000)
    To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ...
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    Factors affecting acoustically triggered release of drugs from polymeric micelles 

    Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)
    A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...
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    Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles 

    Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)
    The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...
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    Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide 

    Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)
    Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...
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    The role of cavitation in acoustically activated drug delivery 

    Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Richardson, Eric S.; Christensen, Douglas A.; Pitt, William G. (Elsevier Science Direct, 2005)
    Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
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    The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles 

    Husseini, Ghaleb; O'Neill, Kim L.; Pitt, William G. (Adenine Press, 2005)
    This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...
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    AuthorPitt, William G. (10)
    Husseini, Ghaleb (7)
    Christensen, Douglas A. (5)
    Husseini Ghaleb (5)
    Rapoport, Natalya Y. (4)Diaz de la Rosa, Mario A. (2)O'Neill, Kim L. (2)Roeder, Beverly L. (2)Al-Sayah, Mohammad (1)Bai, Reenu Geetha (1)... View MoreSubject
    Doxorubicin (12)
    Ultrasound (9)Micellar drug delivery (4)Drug Delivery (3)Drug delivery (2)Pluronic (2)Pluronic micelles (2)Acoustic spectroscopy (1)Apoptosis (1)BDIX Rats (1)... View MoreDate Issued2010 - 2020 (4)2000 - 2009 (8)Has File(s)Yes (12)

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