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Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models
(Elsevier, 2006)
The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the ...
The role of cavitation in acoustically activated drug delivery
(Elsevier Science Direct, 2005)
Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
Micelles and nanoparticles for ultrasonic drug and gene delivery
(Elsevier, 2008)
Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ...
Over-Pressure Suppresses Ultrasonic-Induced Drug Uptake
(Elseviser, 2008)
Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent ...
The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles
(Adenine Press, 2005)
This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...
Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment
(Wiley InterSciences, 2008)
The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...
Ultrasound in drug and gene delivery
(Elsevier, 2008)
In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...