Now showing items 1-10 of 22
The Use of Ultrasound and Micelles in Cancer Treatment
(American Scientific Publishers, 2008)
The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such ...
Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound
(American Scientific Publishers, 2007)
Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ...
Factors affecting acoustically triggered release of drugs from polymeric micelles
A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ...
Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide
(American Chemical Society, 2000)
N,N-Diethylacrylamide (NNDEA) was polymerized in the presence of Pluronic P-105 micelles. The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations ...
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
(BioMed Central (BMC), 2002)
Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ...
Photochemical Lithography: Creation of Patterned, Acid Chloride Functionalized Surfaces Using UV Light and Gas-Phase Oxalyl Chloride
(American Chemical Society, 2003)