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Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound
(American Scientific Publishers, 2007)
Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
The role of cavitation in acoustically activated drug delivery
(Elsevier Science Direct, 2005)
Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
(Elsevier, 2002)
The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ...
Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model
(Adenine Press, 2007)
This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test ...
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
(Elsevier, 2001)
The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...
DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
(Elsevier, 2000)
To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ...
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
(Elsevier, 2002)
Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...
The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles
(Adenine Press, 2005)
This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...
Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles
(SAGE Publications, 2009)
We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the ...
Factors affecting acoustically triggered release of drugs from polymeric micelles
(Elsevier, 2000)
A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...