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    Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks 

    Ibrahim, Mihad; Sabouni, Rana; Husseini, Ghaleb; Karami, Abdollah; Bai, Reenu Geetha; Mukhopadhyay, Debasmita (American Scientific Publishers, 2020)
    Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF ...
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    DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study 

    Husseini, Ghaleb; El-Fayoumi, Refaat I.; O'Neill, Kim L.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2000)
    To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ...
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    Factors affecting acoustically triggered release of drugs from polymeric micelles 

    Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)
    A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...
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    Intracellular uptake of Pluronic copolymer: effects of the aggregation state 

    Muniruzzaman, Md.; Marin, Alexander; Luo, Yi; Prestwich, Glenn D.; Pitt, William G.; Husseini, Ghaleb; Rapoport, Natalya Y. (Elsevier, 2002)
    The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ...
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    Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide 

    Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)
    Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...
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    Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles 

    Husseini, Ghaleb; Runyan, Christopher M.; Pitt, William G. (BioMed Central (BMC), 2002)
    Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ...
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    Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment 

    Husseini, Ghaleb; Pitt, William G. (Wiley InterSciences, 2008)
    The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...
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    Ultrasound in drug and gene delivery 

    Pitt, William G. (Elsevier, 2008)
    In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...
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    Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats 

    Staples, Bryant J.; Roeder, Beverly L.; Husseini, Ghaleb; Badamjav, Odgerel; Schaalje, G. Bruce; Pitt, William G. (Springer, 2009)
    Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...
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    Micelles and nanoparticles for ultrasonic drug and gene delivery 

    Husseini, Ghaleb; Pitt, William G. (Elsevier, 2008)
    Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ...
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    AuthorHusseini, Ghaleb (19)Pitt, William G. (18)Husseini Ghaleb (6)Christensen, Douglas A. (4)Rapoport, Natalya Y. (4)Al-Sayah, Mohammad (3)AlSawaftah, Nour Majdi (3)Roeder, Beverly L. (3)Abdel-Hafez, Mamoun (2)Awad, Nahid S. (2)... View MoreSubject
    Ultrasound (35)
    Liposomes (12)Doxorubicin (11)Drug delivery (10)Cancer (9)Chemotherapy (5)Drug Delivery (5)Drug delivery systems (5)Therapeutic use (5)Micellar drug delivery (4)... View MoreDate Issued2010 - 2020 (21)2000 - 2009 (14)Has File(s)Yes (35)

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