Search
Now showing items 1-10 of 52
The effect of pegylation and targeting moieties on the ultrasound-mediated drug release from liposomes
(ACS Publications, 2019)
The use of targeted liposomes encapsulating chemotherapy drugs enhances the specific targeting of cancer cells, thus, reducing the side effects of these agents and providing a more patient-friendly treatment. Targeted ...
Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy
(Taylor and Francis Online, 2019)
Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release ...
Synergistic Nanomedicine: Passive, Active, and Ultrasound-Triggered Drug Delivery in Cancer Treatment
(American Scientific Publishers, 2015)
Nanocarriers are heavily researched as drug delivery vehicles capable of sequestering antineoplastic agents and then releasing their contents at the desired location. The feasibility of using such carriers stems from their ...
Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible?
(American Scientific Publishers, 2012)
Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ...
Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes
(American Scientific Publishers, 2019)
Typical methods used in cancer treatment, including chemotherapy, are debilitating because of the various adverse side effects experienced by cancer patients. The free drug injected into the patient at given doses affects ...
Measuring the Acoustic Release of a Chemotherapeutic Agent from Folate-Targeted Polymeric Micelles
(American Scientific Publishers, 2018)
In this paper, we compare the use of Bayesian filters for the estimation of release and reencapsulation rates of a chemotherapeutic agent (namely Doxorubicin) from nanocarriers in an acoustically activated drug release ...
Synthesis of Metal-Organic Framework from Iron Nitrate and 2,6-Naphthalenedicarboxylic Acid and Its Application as Drug Carrier
(American Scientific Publishers, 2018)
Metal-organic frameworks (MOFs) are highly crystalline porous organic–inorganic materials that are comprised of metal salts and organic linkers. The common synthetic methodologies of MOFs include: solvothermal, microwave-assisted, ...
Modeling and Bias-Robust Estimation of the Acoustic Release of Chemotherapeutics from Liposomes
(American Scientific Publishers, 2019)
This paper models the acoustic drug release of chemotherapeutics from liposomes using a kinetic model that accounts for systematic biases affecting the drug delivery process. An optimal stochastic filter is then proposed ...
Preliminary Modeling of Transfer RNA Kinetics in the Cytoplasm of Escherichia coli Bacteria
(American Scientific Publishers, 2010)
Transfer RNAs (tRNAs) can recognize a specific amino acid from a possible pool of 20. Theyare able to transport these protein building-blocks to the ribosome, the site where amino acids assemble into protein chains. Accurate ...
Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats
(American Scientific Publishers, 2011)
Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...