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dc.contributor.authorAwad, Nahid S.
dc.contributor.authorPaul, Vinod
dc.contributor.authorAl-Sayah, Mohammad
dc.contributor.authorHusseini, Ghaleb
dc.date.accessioned2020-02-03T08:00:03Z
dc.date.available2020-02-03T08:00:03Z
dc.date.issued2019
dc.identifier.citationNahid S. Awad, Vinod Paul, Mohammad H. Al-Sayah & Ghaleb A. Husseini (2019) Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 705-714, DOI:10.1080/21691401.2019.1573175en_US
dc.identifier.issn2169-1401
dc.identifier.urihttp://hdl.handle.net/11073/16588
dc.description.abstractTargeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal formulation with ultrasonic triggering techniques, promises a safe, effective and site-specific breast cancer therapy.en_US
dc.description.sponsorshipCollege of Engineeringen_US
dc.description.sponsorshipDepartment of Chemical Engineeringen_US
dc.description.sponsorshipCollege of Arts and Sciences (CAS)en_US
dc.description.sponsorshipDepartment of Biology, Chemistry and Environmental Sciencesen_US
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Onlineen_US
dc.relation.ispartofseriesAmerican University of Sharjah Student Worken_US
dc.relation.ispartofseriesAmerican University of Sharjah Faculty Worken_US
dc.relation.urihttps://doi.org/10.1080/21691401.2019.1573175en_US
dc.subjectHuman serum albuminen_US
dc.subjectLiposomesen_US
dc.subjectCalceinen_US
dc.subjectBreast canceren_US
dc.subjectUltrasounden_US
dc.titleUltrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapyen_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePostprinten_US
dc.identifier.doi10.1080/21691401.2019.1573175


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