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dc.contributor.authorBelhamadia, Youssef
dc.contributor.authorGrenier, Justin
dc.date.accessioned2020-02-23T08:17:53Z
dc.date.available2020-02-23T08:17:53Z
dc.date.issued2019
dc.identifier.citationBelhamadia Y, Grenier J (2019) Modeling and simulation of hypothermia effects on cardiac electrical dynamics. PLoS ONE 14(5): e0216058. https://doi.org/10.1371/journal.pone.0216058en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11073/16620
dc.description.abstractPrevious experimental evidence has shown the effect of temperature on the action potential duration (APD). It has also been demonstrated that regional cooling of the heart can prolong the APD and promote the termination of ventricular tachycardia. The aim of this study is to demonstrate the effect of hypothermia in suppressing cardiac arrhythmias using numerical modeling. For this purpose, we developed a mathematical model that couples Pennes’ bioheat equation and the bidomain model to simulate the effect of heat on the cardiac action potential. The simplification of the proposed heat–bidomain model to the heat–monodomain model is provided. A suitable numerical scheme for this coupling, based on a time adaptive mesh finite element method, is also presented. First, we performed two-dimensional numerical simulations to study the effect of heat on a regular electrophysiological wave, with the comparison of the calculated and experimental values of Q10. Then, we demonstrated the effect of global hypothermia in suppressing single and multiple spiral waves.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.urihttps://doi.org/10.1371/journal.pone.0216058en_US
dc.titleModeling and simulation of hypothermia effects on cardiac electrical dynamicsen_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePublished versionen_US
dc.identifier.doi10.1371/journal.pone.0216058en_US


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