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dc.contributor.authorAlSawaftah, Nour Majdi
dc.contributor.authorHusseini, Ghaleb
dc.date.accessioned2020-08-19T06:29:28Z
dc.date.available2020-08-19T06:29:28Z
dc.date.issued2020
dc.identifier.citationAl Sawaftah, N. M. & Hussaini, G. A. (2020). Ultrasound-mediated drug delivery in cancer therapy: a review. Journal of Nanoscience and Nanotechnology, 20(12), 7211-7230. doi: doi.org/10.1166/jnn.2020.18877en_US
dc.identifier.issn1533-4899
dc.identifier.urihttp://hdl.handle.net/11073/19723
dc.description.abstractThe use of ultrasound as a medical diagnostic tool began in the 1940s. Ever since, the medical applications of ultrasound have included imaging, tumor ablation, and lithotripsy; however, an ever-increasing body of literature demonstrates that ultrasound has potential in other medical applications, including targeted drug delivery. Site-specific drug delivery involves delivering drugs to diseased areas with a high degree of precision, which is particularly advantageous in cancer treatment as it would minimize the adverse side effects experienced by patients. This review addresses the ability of ultrasound to induce localized and controlled drug release from nanocarriers, namely micelles and liposomes, utilizing thermal and/or mechanical effects. The interactions of ultrasound with micelles and liposomes, the effects of the lipid composition, and ultrasound parameters on the release of encapsulated drugs are discussed. In addition, a survey of the literature detailing some in vitro and in vivo ultrasound triggered drug delivery systems is presented.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Scientific Publishersen_US
dc.relation.urihttps://doi.org/10.1166/jnn.2020.18877en_US
dc.subjectUltrasounden_US
dc.subjectMicelleen_US
dc.subjectLiposomeen_US
dc.subjectTargeted deliveryen_US
dc.subjectCavitationen_US
dc.titleUltrasound-Mediated Drug Delivery in Cancer Therapy: A Reviewen_US
dc.typeArticleen_US
dc.typePostprinten_US
dc.typePeer-Revieweden_US
dc.identifier.doi10.1166/jnn.2020.18877


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