| dc.contributor.author | Pitt, William G. | |
| dc.contributor.author | Husseini, Ghaleb | |
| dc.contributor.author | Roeder, Beverly L. | |
| dc.contributor.author | Dickinson, David J. | |
| dc.contributor.author | Warden, David R. | |
| dc.contributor.author | Hartley, Jonathan M. | |
| dc.contributor.author | Jones, Peter W. | |
| dc.date.accessioned | 2020-08-27T11:13:08Z | |
| dc.date.available | 2020-08-27T11:13:08Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Pitt, W. G., Husseini, G. A., Roeder, B. L., Dickinson, D. J., Warden, D. R., Hartley, J. M., & Jones, P. W. (2011). Preliminary results of combining low frequency low intensity ultrasound and liposomal drug delivery to treat tumors in rats. Journal of Nanoscience and Nanotechnology, 11(3), 1866–1870. https://doi.org/10.1166/jnn.2011.3117 | en_US |
| dc.identifier.issn | 1533-4880 | |
| dc.identifier.uri | http://hdl.handle.net/11073/19736 | |
| dc.description.abstract | Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] and alpha-tocopherol were loaded with Doxorubicin (Dox) using a pH gradient. The liposomal suspension was infused through the tail vein of BDIX rats possessing bilateral intradermal DHD/K12 tumors on their hind legs. Then 20-kHz ultrasound was applied to only one of the tumors for 15 minutes. This therapy was repeated weekly for 4 weeks. The results showed that in five of six rats, the tumors regressed to non-measurable size within 4 weeks. A paired comparison of the normalized size of the insonated and non-insonated tumors in the same rat indicated that the insonated tumors were smaller (p < 0 0001, n = 6 rats, 21 pairs). This observation has significant potential for non-invasive site-specific therapy of solid tumors. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | American Scientific Publishers | en_US |
| dc.relation.uri | https://doi.org/10.1166/jnn.2011.3117 | en_US |
| dc.subject | Ultrasound | en_US |
| dc.subject | Drug Delivery | en_US |
| dc.subject | Liposomes | en_US |
| dc.subject | Doxorubicin | en_US |
| dc.subject | BDIX Rats | en_US |
| dc.subject | Rumor Model | en_US |
| dc.title | Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats | en_US |
| dc.type | Peer-Reviewed | en_US |
| dc.type | Article | en_US |
| dc.type | Published version | en_US |
| dc.identifier.doi | 10.1166/jnn.2011.3117 | |
