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dc.contributor.authorKarmi, Abeer
dc.contributor.authorHusseini, Ghaleb
dc.contributor.authorFaroun, Maryam
dc.contributor.authorSowwan, Mukhles
dc.date.accessioned2020-08-27T11:20:59Z
dc.date.available2020-08-27T11:20:59Z
dc.date.issued2011
dc.identifier.citationKarmi, A., Husseini, G. A., Faroun, M., & Sowwan, M. (2011). Multifunctional nanovehicles for combined 5-fluorouracil and gold nanoparticles based on the nanoprecipitation method. Journal of Nanoscience and Nanotechnology, 11(6), 4675–83.en_US
dc.identifier.issn1533-4880
dc.identifier.urihttp://hdl.handle.net/11073/19737
dc.description.abstractTo facilitate the administration of combined 5-Fluorouracil (5-FU) and gold nanoparticles (for photothermal treatment purposes), we developed 5-FU-gold-poly(lactide-co-glycolic acid) (5-FU-Au- PLGA) nanovehicles, via the nanoprecipitation method. The gold nanoparticles were incorporated inside the 5-FU-PLGA carriers using a roller mixer. Morphological analysis using atomic force microscopy (AFM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), indicated uniform, singly separated spherical nanoparticles (NPs). Drug content, recovery and entrapment in the NPs were approximated using UV-spectrophotometer data. Approximately 26% of nanoparticles were recovered after drying. The percentage of total drug content was about 30%, and the percentage of drug entrapment reached 57%. Electrostatic Force Microscopy images confirmed the presence of gold inside the drug-loaded nanoparticles. We speculate that the 20-nm gold particles were able to diffuse, after 12 hours of mixing (using the roller mixer), into the PLGA matrix through the 100-nm pores (observed by SEM) without affecting the integrity of the drug delivery vehicle. These synthesized nanoparticles show promise as multimodal vehicles in the delivery of chemotherapeutic agents.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Scientific Publishersen_US
dc.relation.urihttps://doi.org/10.1166/jnn.2011.4156en_US
dc.subjectDrug Deliveryen_US
dc.subject5-Fluorouracilen_US
dc.subjectPLGAen_US
dc.subjectNanoprecipitation Methoden_US
dc.subjectGold Nanoparticlesen_US
dc.titleMultifunctional Nanovehicles for Combined 5-Fluorouracil and Gold Nanoparticles Based on the Nanoprecipitation Methoden_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePublished versionen_US
dc.identifier.doi10.1166/jnn.2011.4156


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