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dc.contributor.authorHusseini, Ghaleb
dc.contributor.authorRunyan, Christopher M.
dc.contributor.authorPitt, William G.
dc.date.accessioned2021-01-04T04:41:03Z
dc.date.available2021-01-04T04:41:03Z
dc.date.issued2002
dc.identifier.citationHusseini, G. A., Runyan, C. M., & Pitt, W. G. (2002). Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles. BMC Cancer, 2(1). https://doi.org/10.1186/1471-2407-2-20en_US
dc.identifier.issn1471-2407
dc.identifier.urihttp://hdl.handle.net/11073/19835
dc.description.abstractBackground: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and without the action of ultrasound, while drug uptake was increased with the application of ultrasound. Methods: In this study, the amount of uptake of two fluorescent probes, Lysosensor Green (a pHsensitive probe) and Cell Tracker Orange CMTMR (a pH-independent probe), was measured in HL-60 and HeLa cells. Results: The results of our experiments show that the increase in drug accumulation in the cells as a result of ultrasonication is not due to an increase in endocytosis due to ultrasonication. Conclusions: We hypothesize that sonoporation plays an important role in the acoustically activated drug delivery of chemotherapy drugs delivered from Pluronic micelles/en_US
dc.description.sponsorshipCollege of Engineeringen_US
dc.description.sponsorshipDepartment of Chemical Engineeringen_US
dc.language.isoen_USen_US
dc.publisherBioMed Central (BMC)en_US
dc.relation.ispartofseriesAmerican University of Sharjah Faculty Worken_US
dc.relation.urihttps://doi.org/10.1186/1471-2407-2-20en_US
dc.subjectMicellar drug deliveryen_US
dc.subjectPluronicen_US
dc.subjectFlow cytometryen_US
dc.subjectUltrasounden_US
dc.titleInvestigating the mechanism of acoustically activated uptake of drugs from Pluronic micellesen_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePublished versionen_US
dc.identifier.doi10.1186/1471-2407-2-20


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