| dc.contributor.author | Husseini, Ghaleb | |
| dc.contributor.author | Runyan, Christopher M. | |
| dc.contributor.author | Pitt, William G. | |
| dc.date.accessioned | 2021-01-04T04:41:03Z | |
| dc.date.available | 2021-01-04T04:41:03Z | |
| dc.date.issued | 2002 | |
| dc.identifier.citation | Husseini, G. A., Runyan, C. M., & Pitt, W. G. (2002). Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles. BMC Cancer, 2(1). https://doi.org/10.1186/1471-2407-2-20 | en_US |
| dc.identifier.issn | 1471-2407 | |
| dc.identifier.uri | http://hdl.handle.net/11073/19835 | |
| dc.description.abstract | Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and without the action of ultrasound, while drug uptake was increased with the application of ultrasound. Methods: In this study, the amount of uptake of two fluorescent probes, Lysosensor Green (a pHsensitive probe) and Cell Tracker Orange CMTMR (a pH-independent probe), was measured in HL-60 and HeLa cells. Results: The results of our experiments show that the increase in drug accumulation in the cells as a result of ultrasonication is not due to an increase in endocytosis due to ultrasonication. Conclusions: We hypothesize that sonoporation plays an important role in the acoustically activated drug delivery of chemotherapy drugs delivered from Pluronic micelles/ | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | BioMed Central (BMC) | en_US |
| dc.relation.uri | https://doi.org/10.1186/1471-2407-2-20 | en_US |
| dc.subject | Micellar drug delivery | en_US |
| dc.subject | Pluronic | en_US |
| dc.subject | Flow cytometry | en_US |
| dc.subject | Ultrasound | en_US |
| dc.title | Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles | en_US |
| dc.type | Peer-Reviewed | en_US |
| dc.type | Article | en_US |
| dc.type | Published version | en_US |
| dc.identifier.doi | 10.1186/1471-2407-2-20 | |
