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dc.contributor.authorHusseini, Ghaleb
dc.contributor.authorDiaz de la Rosa, Mario A.
dc.contributor.authorRichardson, Eric S.
dc.contributor.authorChristensen, Douglas A.
dc.contributor.authorPitt, William G.
dc.date.accessioned2021-01-14T06:37:15Z
dc.date.available2021-01-14T06:37:15Z
dc.date.issued2005
dc.identifier.citationGhaleb A. Husseini, Mario A. Diaz de la Rosa, Eric S. Richardson, Douglas A. Christensen, William G. Pitt, The role of cavitation in acoustically activated drug delivery, Journal of Controlled Release, Volume 107, Issue 2, 2005, Pages 253-261, ISSN 0168-3659, https://doi.org/10.1016/j.jconrel.2005.06.015.en_US
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/11073/21270
dc.description.abstractPluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.en_US
dc.description.sponsorshipCollege of Engineeringen_US
dc.description.sponsorshipDepartment of Chemical Engineeringen_US
dc.language.isoen_USen_US
dc.publisherElsevier Science Directen_US
dc.relation.ispartofseriesAmerican University of Sharjah Faculty Worken_US
dc.relation.urihttps://doi.org/10.1016/j.jconrel.2005.06.015en_US
dc.subjectDoxorubicinen_US
dc.subjectPluronic micellesen_US
dc.subjectFluorescence measurementsen_US
dc.subjectCavitation eventsen_US
dc.subjectAcoustic spectroscopyen_US
dc.titleThe role of cavitation in acoustically activated drug deliveryen_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePostprinten_US
dc.identifier.doi10.1016/j.jconrel.2005.06.015


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