• Login
    View Item 
    •   DSpace Home
    • College of Engineering (CEN)
    • Department of Chemical and Biological Engineering
    • View Item
    •   DSpace Home
    • College of Engineering (CEN)
    • Department of Chemical and Biological Engineering
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)

    Thumbnail
    View/ Open
    49MOF review(CMC).pdf (1.188Mb)
    Date
    2017
    Author
    Ibrahim, Mihad
    Sabouni, Rana
    Husseini, Ghaleb
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Postprint
    Metadata
    Show full item record
    Abstract
    Cancer is the uncontrolled growth of cells in the body and is considered as one of the major causes of death globally. There are several cytotoxic chemotherapeutic agents used to treat cancer including methotrexate, 5-fluorouracil, cisplatin, tamoxifen, doxorubicin and others. Although billions of dollars have been spent on cancer research to develop these chemotherapies, it still remains a major illness for mankind partly due to the shortcomings of these therapies. These shortcomings include low targeting specificity, severe side effects (due to high doses) and poor pharmacokinetics. To avoid these drawbacks, anti-cancer drug delivery systems have been developed recently using nanocarriers including liposomes, micelles, polyelectrolyte capsules and others. One of the recent class of nanoparticles investigated for chemotherapeutic use are metal organic frameworks (MOFs) which are hybrid polymers that consist of metal ions or clusters and organic ligands. MOFs are used in many applications including gas/vapor separation, gas storage, catalysis, luminescent materials, and biomedical imaging. These structures have additional features that promote their use as drug carriers in the biomedical field. First, they are nontoxic, biodegradable and have the ability to carry high loadings of the anti-neoplastic agent due to their porous nature. Also, they have well-defined crystalline structures that can be characterized by different analytical techniques and their sizes are suitable to control their in vivo drug release.
    DSpace URI
    http://hdl.handle.net/11073/21313
    External URI
    https://doi.org/10.2174/0929867323666160926151216
    Collections
    • Department of Chemical and Biological Engineering

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsCollege/DeptArchive ReferenceSeriesThis CollectionBy Issue DateAuthorsTitlesSubjectsCollege/DeptArchive ReferenceSeries

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Submission Policies | Terms of Use | Takedown Policy | Privacy Policy | About Us | Contact Us | Send Feedback

    Return to AUS
    Theme by 
    Atmire NV