dc.contributor.author | Marin, Alexander | |
dc.contributor.author | Sun, Hao | |
dc.contributor.author | Husseini, Ghaleb | |
dc.contributor.author | Pitt, William G. | |
dc.contributor.author | Christensen, Douglas A. | |
dc.contributor.author | Rapoport, Natalya Y. | |
dc.date.accessioned | 2021-02-04T05:04:52Z | |
dc.date.available | 2021-02-04T05:04:52Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Alexandre Marin, Hao Sun, Ghaleb A Husseini, William G Pitt, Douglas A Christensen, Natalya Y Rapoport, Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake, Journal of Controlled Release, Volume 84, Issues 1–2, 2002, Pages 39-47, ISSN 0168-3659, https://doi.org/10.1016/S0168-3659(02)00262-6. | en_US |
dc.identifier.issn | 0168-3659 | |
dc.identifier.uri | http://hdl.handle.net/11073/21324 | |
dc.description.abstract | The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells (A2780 and A2780/ADR, respectively), and breast cancer MCF-7 cells. Cavitation events initiated by high-frequency ultrasound were recorded by radical trapping. The onset of transient cavitation and DOX release from micelles were observed at much higher power densities than at low-frequency ultrasound (20–100 kHz). Even a short (15–30 s) exposure to high-frequency ultrasound significantly enhanced the intracellular DOX uptake from PBS, RPMI 1640, and Pluronic micelles. The mechanisms of the observed effects are discussed. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.uri | https://doi.org/10.1016/s0168-3659(02)00262-6 | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | High-frequency Ultrasound | en_US |
dc.subject | Pluronic micelles | en_US |
dc.subject | HL-60 cells | en_US |
dc.subject | A2780 cells | en_US |
dc.subject | A2780/ADR cells | en_US |
dc.subject | MCF-7 cells | en_US |
dc.subject | Multidrug resistance | en_US |
dc.subject | Micellar drug delivery | en_US |
dc.title | Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake | en_US |
dc.type | Peer-Reviewed | en_US |
dc.type | Article | en_US |
dc.type | Postprint | en_US |
dc.identifier.doi | 10.1016/s0168-3659(02)00262-6 | |