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dc.contributor.authorMartins, Ana M.
dc.contributor.authorAhmed, Salma E.
dc.contributor.authorVitor, Rute F.
dc.contributor.authorHusseini, Ghaleb
dc.date.accessioned2021-02-04T06:18:25Z
dc.date.available2021-02-04T06:18:25Z
dc.date.issued2016
dc.identifier.citationMartins A.M., Elgaili S.A., Vitor R.F., Husseini G.A. (2015) Ultrasonic Drug Delivery Using Micelles and Liposomes. In: Ashokkumar M. (eds) Handbook of Ultrasonics and Sonochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-287-470-2_29-1en_US
dc.identifier.isbn9789812874702
dc.identifier.urihttp://hdl.handle.net/11073/21326
dc.description.abstractThe encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid lipid nanoparticles, and others. The surface of nanocarriers can be modified to alter their characteristics and improve their efficiency as drug delivery systems. The addition of polyethylene glycol chains, for example, increases the blood circulation time of nanocapsules and, in some cases, improves their stability. Once the structure of nanocarriers is optimized, the next logical step is to explore the feasibility of using one or several trigger mechanisms to release their therapeutic contents at the required time and space. Abundant literature is available on both internal and external trigger mechanisms in cancer drug delivery. Internal mechanisms include changes in pH, enzyme concentration, and temperature, while external mechanisms include light, magnetic/electromagnetic waves, and acoustic power. This review focuses on the utility of ultrasound and polymeric micelles in cancer drug delivery. The idea is to control the release of chemotherapeutics from micelles to cancerous cells by focusing the ultrasound waves on the diseased tissue while sparing other healthy cells in the body. Thus, the side effects of conventional chemotherapy can be minimized.en_US
dc.description.sponsorshipCollege of Engineeringen_US
dc.description.sponsorshipDepartment of Chemical Engineeringen_US
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesAmerican University of Sharjah Faculty Worken_US
dc.relation.urihttps://doi.org/10.1007/978-981-287-470-2_29-1en_US
dc.subjectDrug delivery systems (DDS)en_US
dc.subjectPluronic®en_US
dc.subjectPolymeric micellesen_US
dc.subjectTriggered releaseen_US
dc.subjectUltrasound (US)en_US
dc.titleUltrasonic Drug Delivery Using Micelles and Liposomesen_US
dc.typeBook chapteren_US
dc.typePostprinten_US
dc.identifier.doi10.1007/978-981-287-470-2_29-1


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