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dc.contributor.authorAlSawaftah, Nour Majdi
dc.contributor.authorPitt, William G.
dc.contributor.authorHusseini, Ghaleb
dc.date.accessioned2021-06-02T12:47:30Z
dc.date.available2021-06-02T12:47:30Z
dc.date.issued2021
dc.identifier.citationThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Pharmacology & Translational Science, ©2021 American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsptsci.1c00066en_US
dc.identifier.issn2575-9108
dc.identifier.urihttp://hdl.handle.net/11073/21492
dc.description.abstractThe delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix (ECM), and limited lymphatic drainage) to deliver anti-cancer drugs with reduced systemic side effects. Liposomes are the most promising of such SDDSs and have been well investigated for cancer therapy. To improve the specificity, bioavailability and anti-cancer efficacy of liposomes at the diseased sites, other strategies such as targeting ligands and stimulus-sensitive liposomes have been developed. This review highlights relevant surface functionalization techniques and stimuli-mediated drug release for enhanced delivery of anti-cancer agents at tumor sites, with a special focus on dual functionalization and design of multi-stimuli responsive liposomes.en_US
dc.description.sponsorshipAmerican University of Sharjahen_US
dc.description.sponsorshipAl-Jalila Foundationen_US
dc.description.sponsorshipAl Qasimi Foundationen_US
dc.description.sponsorshipPatient's Friends Committee-Sharjahen_US
dc.description.sponsorshipBiosciences and Bioengineering Research Instituteen_US
dc.description.sponsorshipDana Gas Endowed Chair for Chemical Engineeringen_US
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.urihttps://doi.org/10.1021/acsptsci.1c00066en_US
dc.subjectCanceren_US
dc.subjectNanocarrieren_US
dc.subjectTargeted deliveryen_US
dc.subjectLiposomesen_US
dc.subjectActive targetingen_US
dc.subjectStimulusen_US
dc.titleDual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatmenten_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePreprinten_US
dc.identifier.doi10.1021/acsptsci.1c00066


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