Three different types of concrete mixes of design strengths 100 MPa, 50 MPa, and 50 MPa lightweight were designed, produced, and analyzed in the effort to quantify their effects on sustainability and economics. An overall comparison taking into consideration the structural, environmental, and economical effectiveness was conducted to find the most beneficial and reliable material to be used in sustainable structures. Different concrete types were used in the design of typical multi story buildings of the same loadings and dimensions. The only input variables in this research are the different mixes of concrete. By fixing the applied loadings and the buildings' dimensions, the three different materials were studied in terms of their effects on the structural design of members, carbon footprint and sustainability, and economics. High strength concrete using microsilica was concluded to be the most effective material to be used in construction with the best effects on sustainability and economics.