Biofilters have been used for decades in the management of nuisance odors that are emitted from the collection and treatment systems of municipal sewage works. Typically hydrogen sulfide (H2S) has been identified as the major odor contributor associated with waste water treatment applications. H2S can be recognized at concentrations of even less than 0.0047 ppm, thus H2S removal systems must have efficiencies exceeding 99% for complete removal of odor from plant facilities. In order to accurately size biofilters for wastewater industries a predictive software tool is required. In this study, based on biofiltration removal kinetics of H2S, a mathematical model has been incorporated into computer software which allows users to design biofilters for municipal wastewater applications, and estimate pre-air conditioning and energy requirements for smooth operations biofilters.