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Evaluation of the interaction potential of synthetic ethylene glycol compounds with nuclear Factor κB
(PKP, 2013)
In the last three decades, nuclear factor κB (NF-κB) has been the focus of many researchers who are interested in understanding the various molecular mechanisms involved in inflammatory diseases and cancer. Interference ...
Efficient and simple protocol employing borohydride systems to design a selective osthol-zirconium (OST-Zr) library from potential natural products
(PKP, 2016)
“Drug likeness” of a molecule is the prime criterion for a molecule to exhibit the desired pharmaceutical activity. A pharmacophore, which describes molecular features that are necessary for molecular recognition of a ...
Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
(Springer Nature, 2011)
Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipocyte ...
Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice
(Public Library of Science, 2011)
Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell ...
Regulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages
(Hindawi, 2010)
NF-𝜅B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-𝜅B in inflammation and atherosclerosis and the regulation of the NF-𝜅B ...
PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
(Sage, 2010)
Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in ...
Assessing test suites of extended finite state machines against model and code based faults
(John Wiley & Sons, 2021)
Tests can be derived from extended finite state machine (EFSM) specifications considering the coverage of single-transfer faults, all transitions using a transition tour, all-uses, edge-pair, and prime path with side trip. ...
Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-κB via IκBα Negative Regulation
(The American Society for Cell Biology, 2007)
Nuclear factor κB (NF-κB) subunits comprise a family of eukaryotic transcription factors that are critically involved in cell proliferation, inflammation, and apoptosis. Under basal conditions, NF-κB subunits are kept under ...
The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARγ-dependent and PPARγ-independent mechanisms
(Elsevier, 2008)
The adipocyte-derived secretory protein adiponectin functions as an insulin-sensitizing agent. In plasma, adiponectin exists as low, medium, and high molecular weight oligomers. Treatment with trans-10, cis-12 conjugated ...
The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
(Springer Nature, 2005)
Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP₁, which functions as a negative regulator ...