Now showing items 1-15 of 15

    • Comprehensive Study of a Diabetes Mellitus Mathematical Model Using Numerical Methods with Stability and Parametric Analysis 

      AlShurbaji, Mohammad; Kader, Lamis Abdul; Hannan, Hadia; Mortula, Maruf; Husseini, Ghaleb (MDPI, 2023-01-04)
      Diabetes is sweeping the world as a silent epidemic, posing a growing threat to public health. Modeling diabetes is an effective method to monitor the increasing prevalence of diabetes and develop cost-effective strategies ...
    • Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment 

      AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (American Chemical Society, 2021)
      The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix ...
    • Effect of phospholipid head group on ultrasound‑triggered drug release and cellular uptake of immunoliposomes 

      Awad, Nahid S.; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Nature, 2023)
      Liposomes are the most successful nanoparticles used to date to load and deliver chemotherapeutic agents to cancer cells. They are nano-sized vesicles made up of phospholipids, and targeting moieties can be added to their ...
    • Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy 

      AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (Elsevier, 2023)
      The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the ...
    • Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment 

      Almajed, Zeyad Mohamed; AlSawaftah, Nour Majdi; Sulieman, Hana; Husseini, Ghaleb (American Scientific Publishers, 2023-07)
      Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. ...
    • Liposomes for the Treatment of Brain Cancer — A Review 

      Raju, Richu; Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-06-25)
      Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain ...
    • Modeling of Anti-cancer Drug Release Kinetics from Liposomes and Micelles: A review 

      AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (Institute of Electrical and Electronics Engineers, 2021)
      Nanocarriers, such as liposomes and micelles, were developed to enhance the delivery of therapeutic drugs to malignant tissues. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from ...
    • Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review 

      AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (IEEE, 2021)
      Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. ...
    • Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes 

      Hamidu, Aisha; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023)
      Cancer is one of the leading causes of death worldwide. Because each person’s cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly ...
    • Scaffold‑based 3D cell culture models in cancer research 

      Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (Springer Nature, 2024)
      Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown ...
    • Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review 

      Kawak, Paul S.; AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (MDPI, 2026-08-26)
      Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective ...
    • Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells 

      AlSawaftah, Nour Majdi; Awad, Nahid S.; Paul, Vinod; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (Nature, 2021)
      Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency ...
    • Ultrasound-responsive Nanocarriers in Cancer Treatment: a review 

      Awad, Nahid S.; Paul, Vinod; Haar, Gail ter; Allen, Theresa M.; Pitt, William G.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)
      The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...
    • Ultrasound-triggered Immunotherapy for Cancer Treatment: An Update 

      Mukhopadhyay, Debasmita; Ahmed, Amal Elsadig Elamir; Sano, Catherine; Awad, Nahid S.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Bentham, 2021)
    • Ultrasound‑triggered herceptin liposomes for breast cancer therapy 

      Elamir, Amal; Ajith, Saniha Aysha; AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Mukhopadhyay, Debasmita; Paul, Vinod; Al-Sayah, Mohammad; Awad, Nahid S.; Husseini, Ghaleb (Nature, 2021)
      The functionalization of liposomes with monoclonal antibodies is a potential strategy to increase the specificity of liposomes and reduce the side-effects associated with chemotherapeutic agents. The active targeting of ...