Browsing Department of Biology, Chemistry and Environmental Sciences by Author "39a4b437-ea6d-4e49-9cd9-f3d3d04b35de"
Now showing items 1-18 of 18
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Antiamoebic activity of plant‑based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492)
Anwar, Areeba; Ting, Elaine Lim Siew; Anwar, Ayaz; Ain, Noor ul; Faizi, Shaheen; Shah, Muhammad Raza; Khan, Naveed; Siddiqui, Ruqaiyyah (Springer, 2020)Acanthamoeba spp. are the causative agent of Acanthamoeba keratitis and granulomatous amoebic encephalitis (GAE). The current options to treat Acanthamoeba infections have limited success. Silver nanoparticles show ... -
Antibacterial Activities of Selected Pure Compounds Isolated from Gut Bacteria of Animals Living in Polluted Environments
Akbar, Noor; Siddiqui, Ruqaiyyah; Iqbal, Mazhar; Khan, Naveed (MDPI, 2020)Antibiotic resistance is a global threat to public health, further accelerated by the misuse of antibiotics in humans and animals. Our recent studies have shown that gut bacteria of animals living in polluted environments ... -
Antitumour Activities of Selected Pure Compounds Identified from the Serum of Crocodylus porosus, Malayopython reticulatus, Varanus salvator and Cuora kamaroma amboinensis
Jeyamogan, Shareni; Khan, Naveed; Siddiqui, Ruqaiyyah (Asian Pacific Organization for Cancer Prevention, 2021)Objectives: Here we determined antitumour effects of purified compounds such as Valdecoxib, Rofecoxib, L-Methionine and Artocarpin against cancer cell lines. Methods: Using purified compounds, assays were performed to ... -
Drug Discovery against Acanthamoeba Infections: Present Knowledge and Unmet Needs
Elsheikha, Hany M.; Siddiqui, Ruqaiyyah; Khan, Naveed (MDPI, 2020)Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of ... -
Effects of Shape and Size of Cobalt Phosphate Nanoparticles against Acanthamoeba castellanii
Anwar, Ayaz; Fung, Leong Chi; Anwar, Areeba; Jagadish, Priyanka; Numan, Arshid; Khalid, Mohammad; Shahabuddin, Syed; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed (MDPI, 2019)T4 genotype Acanthamoeba are opportunistic pathogens that cause two types of infections, including vision-threatening Acanthamoeba keratitis (AK) and a fatal brain infection known as granulomatous amoebic encephalitis ... -
Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae
Mungroo, Mohammad Ridwane; Anwar, Ayaz; Khan, Naveed; Siddiqui, Ruqaiyyah (ACS Publications, 2020)Balamuthia mandrillaris and Naegleria fowleri are free-living amoebae that cause infection of the central nervous system, granulomatous amoebic encephalitis (GAE) and primary amoebic meningoencephalitis (PAM), respectively. ... -
Gut bacteria of Cuora amboinensis (turtle) produce broad-spectrum antibacterial molecules
Akbar, Noor; Khan, Naveed Ahmed; Sagathevan, K; Iqbal, Mazhar; Tawab, Abdul; Siddiqui, Ruqaiyyah (Nature Research, 2019)Antimicrobial resistance is a major threat to human health, hence there is an urgent need to discover antibacterial molecule(s). Previously, we hypothesized that microbial gut flora of animals are a potential source of ... -
Gut Bacteria of Water Monitor Lizard (Varanus salvator) Are a Potential Source of Antibacterial Compound(s)
Akbar, Noor; Siddiqui, Ruqaiyyah; Sagathevan, K; Iqbal, Mazhar; Khan, Naveed Ahmed (MDPI, 2019)For the past few decades, there has been limited progress in the development of novel antibacterials. Previously, we postulated that the gut microbiota of animals residing in polluted environments are a forthcoming supply ... -
HBN Nanoparticle-Assisted Rapid Thermal Cycling for the Detection of Acanthamoeba
Rasheed, Abdul Khaliq; Siddiqui, Ruqaiyyah; Ahmed, Salma Mohammed Kabir; Gabriel, Shobana; Jalal, Mohammed Zayan; John, Akbar; Khan, Naveed (MDPI, 2020)Acanthamoeba are widely distributed in the environment and are known to cause blinding keratitis and brain infections with greater than 90% mortality rate. Currently, polymerase chain reaction (PCR) is a highly sensitive ... -
Heterometrus spinifer: An Untapped Source of Anti-Tumor Molecules
Soopramanien, Morhanavallee; Khan, Naveed; Ghimire, Ajnish; Sagathevan, K; Siddiqui, Ruqaiyyah (MDPI, 2020)Despite intensive research, cancer incidence and mortality continue to rise. Consequently, the necessity to develop effective anti-cancer therapy is apparent. We have recently shown that the gut bacteria of animals living ... -
In vitro effects of multi-purpose contact lens disinfecting solutions towards survivability of Acanthamoeba genotype T4 in Malaysia
Hussain, Rosnani Hanim Mohd; Afiqah, Wan Nur; Abdul Ghani, Mohamed Kamel; Khan, Naveed; Siddiqui, Ruqaiyyah; Anuar, Tengku Shahrul (Elsevier B.V., 2021)The incidence of Acanthamoeba keratitis has been increasing since the previous decades, especially among contact lens users. This infection is majorly caused by the use of ineffective contact lens disinfecting solution. ... -
Isoniazid Conjugated Magnetic Nanoparticles Loaded with Amphotericin B as a Potent Antiamoebic Agent against Acanthamoeba castellanii
Iqbal, Kawish; Abdelnasir, Sumayah; Anwar, Ayaz; Iqbal, Kanwal Muhammad; Shah, Muhammad Raza; Anwar, Areeba; Siddiqui, Ruqaiyyah; Khan, Naveed (MDPI, 2020)The pathogenic free-living amoeba, Acanthamoeba castellanii, is responsible for a rare but deadly central nervous system infection, granulomatous amoebic encephalitis and a blinding eye disease called Acanthamoeba keratitis. ... -
Metronidazole conjugated magnetic nanoparticles loaded with amphotericin B exhibited potent effects against pathogenic Acanthamoeba castellanii belonging to the T4 genotype
Abdelnasir, Sumayah; Anwar, Ayaz; Kawish, Muhammad; Anwar, Areeba; Shah, Muhammad Raza; Siddiqui, Ruqaiyyah; Khan, Naveed (Springer, 2020)Acanthamoeba castellanii can cause granulomatous amoebic encephalitis and Acanthamoeba keratitis. Currently, no single drug has been developed to effectively treat infections caused by Acanthamoeba. Recent studies have ... -
Novel Azoles as Antiparasitic Remedies against Brain-Eating Amoebae
Anwar, Ayaz; Mungroo, Mohammad Ridwane; Khan, Simal; Fatima, Itrat; Rafique, Rafaila; Khan, Khalid Mohammed; Siddiqui, Ruqaiyyah; Khan, Naveed (MDPI, 2020)Balamuthia mandrillaris and Naegleria fowleri are opportunistic protozoan pathogens capable of producing infection of the central nervous system with more than 95% mortality rate. Previously, we have synthesized several ... -
Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba
Siddiqui, Ruqaiyyah; Roberts, Stephen K.; Ong, Timothy Yu Yee; Mungroo, Mohammad Ridwane; Anwar, Areeba; Khan, Naveed Ahmed (Springer Nature, 2019)Background: Acanthamoeba is well known to produce a blinding keratitis and serious brain infection known as encephalitis. Effective treatment is problematic, and can continue up to a year, and even then, recurrence can ... -
Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity
Soopramanien, Morhanavallee; Khan, Naveed; Abdelnasir, Sumayah; Sagathevan, K; Siddiqui, Ruqaiyyah (Asian Pacific Organization for Cancer Prevention (APOCP), 2020)It is noteworthy that several animal species are known to withstand high levels of radiation, and are exposed to heavy metals but rarely been reported to develop cancer. For example, the scorpion has been used as folk ... -
Transcriptome analysis of Escherichia coli K1 after therapy with hesperidin conjugated with silver nanoparticles
Masri, Abdulkader; Khan, Naveed; Zoqratt, Muhammad Zarul Hanifah Md; Ayub, Qasim; Anwar, Ayaz; Rao, Komal; Shah, Muhammad Raza; Siddiqui, Ruqaiyyah (BioMed Central Ltd, 2021)Backgrounds: Escherichia coli K1 causes neonatal meningitis. Transcriptome studies are indispensable to comprehend the pathology and biology of these bacteria. Recently, we showed that nanoparticles loaded with Hesperidin ... -
Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation
Anwar, Areeba; Siddiqui, Ruqaiyyah; Khan, Naveed (MDPI, 2020)Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular ...