Browsing Department of Biology, Chemistry and Environmental Sciences by Author "6abfb482-3d09-4c8c-b864-b40fb85987a3"
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Antiamoebic activity of plant‑based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492)
Anwar, Areeba; Ting, Elaine Lim Siew; Anwar, Ayaz; Ain, Noor ul; Faizi, Shaheen; Shah, Muhammad Raza; Khan, Naveed; Siddiqui, Ruqaiyyah (Springer, 2020)Acanthamoeba spp. are the causative agent of Acanthamoeba keratitis and granulomatous amoebic encephalitis (GAE). The current options to treat Acanthamoeba infections have limited success. Silver nanoparticles show ... -
Effects of Shape and Size of Cobalt Phosphate Nanoparticles against Acanthamoeba castellanii
Anwar, Ayaz; Fung, Leong Chi; Anwar, Areeba; Jagadish, Priyanka; Numan, Arshid; Khalid, Mohammad; Shahabuddin, Syed; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed (MDPI, 2019)T4 genotype Acanthamoeba are opportunistic pathogens that cause two types of infections, including vision-threatening Acanthamoeba keratitis (AK) and a fatal brain infection known as granulomatous amoebic encephalitis ... -
Isoniazid Conjugated Magnetic Nanoparticles Loaded with Amphotericin B as a Potent Antiamoebic Agent against Acanthamoeba castellanii
Iqbal, Kawish; Abdelnasir, Sumayah; Anwar, Ayaz; Iqbal, Kanwal Muhammad; Shah, Muhammad Raza; Anwar, Areeba; Siddiqui, Ruqaiyyah; Khan, Naveed (MDPI, 2020)The pathogenic free-living amoeba, Acanthamoeba castellanii, is responsible for a rare but deadly central nervous system infection, granulomatous amoebic encephalitis and a blinding eye disease called Acanthamoeba keratitis. ... -
Metronidazole conjugated magnetic nanoparticles loaded with amphotericin B exhibited potent effects against pathogenic Acanthamoeba castellanii belonging to the T4 genotype
Abdelnasir, Sumayah; Anwar, Ayaz; Kawish, Muhammad; Anwar, Areeba; Shah, Muhammad Raza; Siddiqui, Ruqaiyyah; Khan, Naveed (Springer, 2020)Acanthamoeba castellanii can cause granulomatous amoebic encephalitis and Acanthamoeba keratitis. Currently, no single drug has been developed to effectively treat infections caused by Acanthamoeba. Recent studies have ... -
Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba
Siddiqui, Ruqaiyyah; Roberts, Stephen K.; Ong, Timothy Yu Yee; Mungroo, Mohammad Ridwane; Anwar, Areeba; Khan, Naveed Ahmed (Springer Nature, 2019)Background: Acanthamoeba is well known to produce a blinding keratitis and serious brain infection known as encephalitis. Effective treatment is problematic, and can continue up to a year, and even then, recurrence can ... -
Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation
Anwar, Areeba; Siddiqui, Ruqaiyyah; Khan, Naveed (MDPI, 2020)Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular ...