Browsing by Author "2e92357e-9e31-4b8d-b438-1b0d0cee3b34"
Now showing items 1-16 of 16
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Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes
Zafar, Mah Noor; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2023)To improve currently available cancer treatments, nanomaterials are employed as smart drug delivery vehicles that can be engineered to locally target cancer cells and respond to stimuli. Nanocarriers can entrap chemotherapeutic ... -
A Comparative Analysis of Numerical Methods for Solving the Leaky Fire and Integrate Model
El Masri, Ghinwa; Ali, Asma; Abuwatfa, Waad Hussein; Mortula, Maruf; Husseini, Ghaleb (MDPI, 2023)The human nervous system is one of the most complex systems of the human body. Understanding its behavior is crucial in drug discovery and developing medical devices. One approach to understanding such a system is to model ... -
A Comprehensive Review on Membrane Fouling: Mathematical Modelling, Prediction, Diagnosis, and Mitigation
AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Darwish, Naif; Husseini, Ghaleb (MDPI, 2021)Membrane-based separation has gained increased popularity over the past few decades, particularly reverse osmosis (RO). A major impediment to the improved performance of membrane separation processes, in general, is membrane ... -
Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review
Ibrahim, Mihad; Abuwatfa, Waad Hussein; Awad, Nahid S.; Sabouni, Rana; Husseini, Ghaleb (MDPI, 2022)Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse ... -
Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy
Ali, Amaal Abdulraqeb; Abuwatfa, Waad Hussein; Al-Sayah, Mohammad; Husseini, Ghaleb (MDPI, 2022)With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold ... -
In Vitro Cell Work of Two Types of Targeted Nanoparticles with Ultrasound Triggering
Abuwatfa, Waad Hussein (2020-11)Targeted liposomes have shown promising potential as effective chemotherapeutics delivery vehicles in Smart Drug Delivery Systems (SDDSs). Upon accumulation and internalization at the tumor site, the liposomes need to be ... -
In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes
Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Farooq, Afifa; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable ... -
Lessons learned from the underrepresentation of women in STEM: AI-enabled solutions and more
Abuwatfa, Waad Hussein; Zamel, Nada; Al-Othman, Amani (Elsevier, 2021)The absence of women in STEM and energy sectors is driven by discrimination and socio-cultural factors. A greater number of women “leak out” from Energy and STEM fields than men. AI-enabled solutions offer analysis tools ... -
Liposomes for the Treatment of Brain Cancer — A Review
Raju, Richu; Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-06-25)Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain ... -
Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy
Al Bostami, Rouba D.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022-08)Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient ... -
A Review on Membrane Biofouling: Prediction, Characterization, and Mitigation
AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Darwish, Naif; Husseini, Ghaleb (MDPI, 2022-12-15)Water scarcity is an increasing problem on every continent, which instigated the search for novel ways to provide clean water suitable for human use; one such way is desalination. Desalination refers to the process of ... -
A Review on Membrane Fouling Prediction Using Artificial Neural Networks (ANNs)
Abuwatfa, Waad Hussein; AlSawaftah, Nour Majdi; Darwish, Naif A.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-07-24)Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of ... -
Scaffold‑based 3D cell culture models in cancer research
Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (Springer Nature, 2024)Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown ... -
Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
Abuwatfa, Waad Hussein; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven ... -
Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment
Awad, Nahid S.; Salkho, Najla; Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2023)Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. ... -
Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review
Bahutair, Wafa N.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022)Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems ...