Now showing items 101-120 of 133

    • Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)
      Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
    • Remote Labs and Game-Based Learning for Process Control 

      Zaulkerman, Imran; Husseini, Ghaleb; Loughlin, Kevin F.; Mohebzada, Jamshaid G.; El Gaml, Moataz (Chemical Engineering Education, 2013)
      Social networking platforms and computer games represent a natural informal learning environment for the current generation of learners in higher education. This paper explores the use of game-based learning in the context ...
    • A Review on Membrane Biofouling: Prediction, Characterization, and Mitigation 

      AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Darwish, Naif; Husseini, Ghaleb (MDPI, 2022-12-15)
      Water scarcity is an increasing problem on every continent, which instigated the search for novel ways to provide clean water suitable for human use; one such way is desalination. Desalination refers to the process of ...
    • A Review on Membrane Fouling Prediction Using Artificial Neural Networks (ANNs) 

      Abuwatfa, Waad Hussein; AlSawaftah, Nour Majdi; Darwish, Naif A.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-07-24)
      Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of ...
    • Review on Triggered Liposomal Drug Delivery with a Focus on Ultrasound 

      Moussa, Hesham Gamal; Martins, Ana M.; Husseini, Ghaleb (Bentham Science Publishers, 2015)
      Chemotherapy is widely used for cancer treatment; however, it causes unwanted side effects in patients. To avoid these adverse effects, nanocarriers have been developed, which can be loaded with the chemotherapeutic agents, ...
    • Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats 

      Staples, Bryant J.; Roeder, Beverly L.; Husseini, Ghaleb; Badamjav, Odgerel; Schaalje, G. Bruce; Pitt, William G. (Springer, 2009)
      Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...
    • Scaffold‑based 3D cell culture models in cancer research 

      Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (Springer Nature, 2024)
      Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown ...
    • Self-aligned mechanical attachment of carbon nanotubes to silicon dioxide structures by selective silicon dioxide chemical-vapor deposition 

      Whittaker, Jed D.; Brink, Markus; Husseini, Ghaleb; Linford, Matthew R.; Davis, Robert C. (American Institute of Physics (AIP), 2003)
      A self-aligned thin-film deposition technique was developed to mechanically attach carbon nanotubes to surfaces for the fabrication of structurally robust nanotube-based nanomechanical devices. Single-walled carbon nanotubes ...
    • Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide 

      Pruitt, John D.; Husseini, Ghaleb; Rapoport, Natalya Y.; Pitt, William G. (American Chemical Society, 2000)
      N,N-Diethylacrylamide (NNDEA) was polymerized in the presence of Pluronic P-105 micelles. The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations ...
    • State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems 

      Alex, Meera; AlSawaftah, Nour Majdi; Husseini, Ghaleb (MDPI, 2024-03-30)
      Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive ...
    • Synergistic Nanomedicine: Passive, Active, and Ultrasound-Triggered Drug Delivery in Cancer Treatment 

      Elkhodiry, Mohamed A.; Momah, Christian C.; Suwaidi, Shaima; Gadalla, Dina; Martins, Ana M.; Vitor, Rute F.; Husseini, Ghaleb (American Scientific Publishers, 2015)
      Nanocarriers are heavily researched as drug delivery vehicles capable of sequestering antineoplastic agents and then releasing their contents at the desired location. The feasibility of using such carriers stems from their ...
    • Synthesis of Metal-Organic Framework from Iron Nitrate and 2,6-Naphthalenedicarboxylic Acid and Its Application as Drug Carrier 

      Ibrahim, Mihad; Sabouni, Rana; Husseini, Ghaleb (American Scientific Publishers, 2018)
      Metal-organic frameworks (MOFs) are highly crystalline porous organic–inorganic materials that are comprised of metal salts and organic linkers. The common synthetic methodologies of MOFs include: solvothermal, microwave-assisted, ...
    • Systems and Methods for Targeted Breast Cancer Therapies 

      Husseini, Ghaleb; Al-Sayah, Mohammad; Ahmed, Amal Elsadig Elamir (2020-12-15)
      Systems and methods for producing liposomes , including control liposomes and immunoliposomes targeting breast cancer are provided . Systems and methods for treating breast cancer , using targeted immunoliposomes produced ...
    • Systems and Methods for Targeted Breast Cancer Therapies 

      Husseini, Ghaleb; Al-Sayah, Mohammad; Ahmed, Amal Elsadig Elamir (2024-01-09)
      Systems and methods for producing liposomes, including control liposomes and immunoliposomes targeting breast cancer are provided. Systems and methods for treating breast cancer, using targeted immunoliposomes produced ...
    • Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound 

      Ben-Daya, Mohamed; Paul, Vinod; Awad, Nahid S.; AlSawaftah, Nour Majdi; Al-Sayah, Mohammad; Husseini, Ghaleb (American Science Publishers, 2021)
      The successful targeting of tumors can be achieved by conjugating targeting moieties to nanoparticles. These modifications allow nannocarriers to achieve greater targeting specificity through binding to specific receptors ...
    • Targeting the Folate Receptor: Effects of Conjugating Folic Acid to DOX Loaded Polymeric Micelles 

      Elkhodiry, Mohamed A.; Husseini, Ghaleb; Velluto, Diana (Bentham Science Publishers, 2016)
      In this paper, we report on a potential cancer drug delivery system that utilizes the ligand targeting of the folate receptor. Our drug delivery system consists of Pluronic-P105 micelles, targeted with folic acid moieties. ...
    • Technique for Drug and Gene Delivery to the Cell Cytosol 

      Pitt, William G.; Husseini, Ghaleb (2015-04-07)
      Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the ...
    • Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems 

      Abuwatfa, Waad Hussein; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven ...
    • Toxicological impact of nanoparticles on human health: A review 

      Mohamed, Omnia A.; Ajith, Saniha Aysha; Sabouni, Rana; Husseini, Ghaleb; Karami, Abdollah; Bai, Renu Geetha (American Scientific Publishers, 2022)
      Nanotechnology is a rapidly growing industry where nanomaterials are used in almost every field, including electronics, cosmetics, engineering, household products, biotechnology and medicine. Nanoparticles (NPs) have unique ...
    • Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review 

      Kawak, Paul S.; AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (MDPI, 2026-08-26)
      Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective ...