Browsing by Author "52d629dc-7d2f-47b9-aa2d-258b92e45ae1"
Now showing items 121-133 of 133
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Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells
AlSawaftah, Nour Majdi; Awad, Nahid S.; Paul, Vinod; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (Nature, 2021)Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency ... -
Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment
Awad, Nahid S.; Salkho, Najla; Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2023)Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. ... -
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ... -
Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review
Bahutair, Wafa N.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022)Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems ... -
Ultrasound-Induced Calcein Release From eLiposomes
Lattin, James R.; Pitt, William G.; Belnap, David M.; Husseini, Ghaleb (Elsevier, 2012)Ultrasound is explored as a method of inducing the release of encapsulated materials from eLiposomes, defined as liposomes containing emulsion droplets. Emulsions were formed using perfluorohexane and perfluoropentane. ... -
Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study
Martins, Ana M.; Tanbour, Rafeeq Kamal; Elkhodiry, Mohamed A.; Husseini, Ghaleb (De Gruyter, 2016)The aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation ... -
Ultrasound-Mediated Drug Delivery in Cancer Therapy: A Review
AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Scientific Publishers, 2020)The use of ultrasound as a medical diagnostic tool began in the 1940s. Ever since, the medical applications of ultrasound have included imaging, tumor ablation, and lithotripsy; however, an ever-increasing body of literature ... -
Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system
AlSawaftah, Nour Majdi; Paul, Vinod; Kosaji, Doua Jamal; Khabbaz, Leen; Awad, Nahid S.; Husseini, Ghaleb (Taylor & Francis, 2022)Targeted liposomes enable the delivery of encapsulated chemotherapeutics to tumours by targeting specific receptors overexpressed on the surfaces of cancer cells; this helps in reducing the systemic side effects associated ... -
Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer
Awad, Nahid S.; Haider, Mohamed; Paul, Vinod; AlSawaftah, Nour Majdi; Jagal, Jayalakshmi; Pasricha, Renu; Husseini, Ghaleb (MDPI, 2021)Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their ... -
Use of Model Predictive Control and Artificial Neural Networks to Optimize the Ultrasonic Release of a Model Drug From Liposomes
Moussa, Hesham Gamal; Husseini, Ghaleb; Abdel-Jabbar, Nabil; Ahmed, Salma E. (IEEE, 2017)The use of echogenic liposomes to deliver chemotherapeutic agents for cancer treatment has gained wide recognition in the last 20 years. Cancerous cells can develop multiple drug resistance (MDR), in part, due to the drop ... -
The Use of Ultrasound and Micelles in Cancer Treatment
Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2008)The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such ... -
The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes
Ahmed, Salma E.; Martins, Ana M.; Husseini, Ghaleb (Taylor & Francis, 2014)Several drug delivery systems have been investigated to reduce the side effects of chemotherapy by encapsulating the therapeutic agent in a nanosized carrier until it reaches the tumor site. Many of these particles are ... -
Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles
Husseini, Ghaleb; Mjalli, Farouq Sabri; Pitt, William G.; Abdel-Jabbar, Nabil (SAGE Publications, 2009)We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the ...