Browsing by Author "52d629dc-7d2f-47b9-aa2d-258b92e45ae1"
Now showing items 61-80 of 133
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Kinetics and thermodynamics of acoustic release of doxorubicin from non-stabilized polymeric micelles
Husseini, Ghaleb; Abouelnasr, Dana; Pitt, William G.; Assaleh, Khaled; Farahat, Lujein O.; Fahadi, Jalal (Elsevier, 2010)This paper studies the thermodynamic characteristics of ultrasound-activated release of Doxorubicin (Dox) from micelles. The release and re-encapsulation of Dox into Pluronic® P105 micelles was measured by recording the ... -
Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature
Husseini, Ghaleb; Diaz de la Rosa, Mario A.; AlAqqad, Emad O.; Al Mamary, Saif; Kadimati, Yaman; Al Baik, Abdullah; Pitt, William G. (Elsevier, 2011)Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of ... -
The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound
AlSawaftah, Nour Majdi; Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2022)Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable ... -
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ... -
Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment
Almajed, Zeyad Mohamed; AlSawaftah, Nour Majdi; Sulieman, Hana; Husseini, Ghaleb (American Scientific Publishers, 2023-07)Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. ... -
Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
Salkho, Najla; Turki, Renad; O, Guessoum; Martins, Ana M.; Vitor, Rute F.; Husseini, Ghaleb (Bentham Science, 2017)The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a ... -
Liposomes for the Treatment of Brain Cancer — A Review
Raju, Richu; Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-06-25)Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain ... -
Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery
Al Basha, Sara; Salkho, Najla; Dalibalta, Sarah; Husseini, Ghaleb (Bentham Science Publishers, 2019)Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common ... -
Mapping of Embedded Functionalized Carbon Nanotubes in Poly(vinyl alcohol)/Nanotube Composite Using Electrostatic Force Microscopy
Ghabboun, Jamal; Husseini, Ghaleb; Faroun, Maryam; Karmi, Abeer; Hawash, Zafer; Hayek, Iman; Sowwan, Mukhles (Taylor & Francis, 2012)In the present study, electrostatic force microscopy (EFM) was used as a nondestructive tool for mapping individual functionalized single-wall carbon nanotubes (SWCNTs) incorporated in a poly(vinyl alcohol) (PVA)/CNT ... -
Mathematical modeling of microbubble cavitation at 70 kHz and the importance of the subharmonic in drug delivery from micelles
Diaz de la Rosa, Mario A.; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2013)In order to gain insight into the experimental observation of ultrasound-induced release of drugs from micelles, we modeled the dynamic oscillations of a 10-μm-diameter bubble insonated at 70 kHz. The Parlitz modification ... -
Measuring the Acoustic Release of a Chemotherapeutic Agent from Folate-Targeted Polymeric Micelles
Abusara, Ayah Mahmoud; Abdel-Hafez, Mamoun; Husseini, Ghaleb (American Scientific Publishers, 2018)In this paper, we compare the use of Bayesian filters for the estimation of release and reencapsulation rates of a chemotherapeutic agent (namely Doxorubicin) from nanocarriers in an acoustically activated drug release ... -
Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin
Fatima, Syeda Fiza; Sabouni, Rana; Husseini, Ghaleb; Paul, Vinod; Gomaa, Hassan (MDPI, 2024)Metal-organic frameworks (MOFs) are excellent candidates for a range of applications because of their numerous advantages, such as high surface area, porosity, and thermal and chemical stability. In this study, microwave ... -
Modeling and Bias-Robust Estimation of the Acoustic Release of Chemotherapeutics from Liposomes
Wadi, Ali; Abdel-Hafez, Mamoun; Husseini, Ghaleb (American Scientific Publishers, 2019)This paper models the acoustic drug release of chemotherapeutics from liposomes using a kinetic model that accounts for systematic biases affecting the drug delivery process. An optimal stochastic filter is then proposed ... -
Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model
Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G. (Adenine Press, 2007)This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test ... -
Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments
Raju, Richu; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2024)Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is ... -
Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review
AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (IEEE, 2021)Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. ... -
Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes
Almajed, Zeyad Mohamed; Salkho, Najla; Sulieman, Hana; Husseini, Ghaleb (MDPI, 2022-12-05)Targeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model ... -
Multi-Model Investigation and Adaptive Estimation of the Acoustic Release of a Model Drug From Liposomes
Wadi, Ali; Abdel-Hafez, Mamoun; Husseini, Ghaleb; Paul, Vinod (IEEE, 2019)This paper researches a suitable mathematical model that can reliably predict the release of a model drug (namely calcein) from biologically targeted liposomal nanocarriers triggered by ultrasound. Using mathematical models, ... -
Multifunctional Nanovehicles for Combined 5-Fluorouracil and Gold Nanoparticles Based on the Nanoprecipitation Method
Karmi, Abeer; Husseini, Ghaleb; Faroun, Maryam; Sowwan, Mukhles (American Scientific Publishers, 2011)To facilitate the administration of combined 5-Fluorouracil (5-FU) and gold nanoparticles (for photothermal treatment purposes), we developed 5-FU-gold-poly(lactide-co-glycolic acid) (5-FU-Au- PLGA) nanovehicles, via the ... -
Nanoparticle-based materials in anticancer drug delivery: Current and future prospects
Ajith, Saniha Aysha; Almomani, Fares; Elhissi, Abdelbary; Husseini, Ghaleb (Elsevier, 2023)The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs to the body. However, these ...