Browsing by Author "52d629dc-7d2f-47b9-aa2d-258b92e45ae1"
Now showing items 81-100 of 133
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Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible?
Pitt, William G.; Jack, Daniel R.; Husseini, Ghaleb; Memmott, Brett V. (American Scientific Publishers, 2012)Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ... -
Novel algorithms for accurate DNA base-calling
Mohammed, Omniyah Gul; Assaleh, Khaled; Husseini, Ghaleb; Majdalawieh, Amin (Scientific Research Publishing, 2013)The ability to decipher the genetic code of different species would lead to significant future scientific achievements in important areas, including medicine and agriculture. The importance of DNA sequencing necessitated ... -
Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles
Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G.; Al-Mousa, Alaa Marwan Subhi (Elsevier, 2011)In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to ... -
Optimum ethane recovery in conventional turboexpander process
Chebbi, Rachid; Al-Amoodi, Nahla S.; Abdel-Jabbar, Nabil; Husseini, Ghaleb; Al Mazroui, Khamis A. (Elsevier, 2010)Ethane recovery in a conventional turboexpander process is optimized considering different demethanizer pressures and different feeds: a lean gas and a rich one. The design variables are varied, while meeting process ... -
pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery
Ahmed, Ahmed H.S; Karami, Abdollah; Sabouni, Rana; Husseini, Ghaleb; Paul, Vinod (Elsevier, 2021)In recent years, the use of metal–organic frameworks (MOFs) as drug nanocarriers has gained attention because of their extraordinary physical and chemical properties. In this work, dual-responsive iron-based MOFs were ... -
pH-Responsive Nanocarriers in Cancer Therapy
AlSawaftah, Nour Majdi; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they ... -
Phase transitions of nanoemulsions using ultrasound: Experimental observations
Singh, Ram; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2012)The ultrasound-induced transformation of perfluorocarbon liquids to gases is of interest in the area of drug and gene delivery. In this study, three independent parameters (temperature, size, and perfluorocarbon species) ... -
Phase transitions of perfluorocarbon nanoemulsion induced with ultrasound: A mathematical model
Pitt, William G.; Singh, Ram; Perez, Krystian X.; Husseini, Ghaleb; Jack, Daniel R. (Elsevier, 2013)While ultrasound has been used in many medical and industrial applications, only recently has research been done on phase transformations induced by ultrasound. This paper presents a numerical model and the predicted results ... -
Photo-Induced Drug Release from Polymeric Micelles and Liposomes: Phototriggering Mechanisms in Drug-Delivery Systems
Salkho, Najla; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs ... -
Photochemical Lithography: Creation of Patterned, Acid Chloride Functionalized Surfaces Using UV Light and Gas-Phase Oxalyl Chloride
Husseini, Ghaleb; Niederhauser, Travis L.; Peacock, Justin G.; Vernon, M. R.; Lua, Yit-Yian; Asplund, Matthew C.; Sevy, Eric T.; Linford, Matthew R. (American Chemical Society, 2003) -
Possible Physical Mechanisms of tRNA Pre-Selection in the Cytoplasm of Escherichia coli Bacteria
Piros, Sandor; Husseini, Ghaleb (American Scientific Publishers, 2010)In a previous publication, we used kinetic models to simulate the physical movement ofthe transfer RNA (tRNA) in the cytoplasm of Escherichia coli and concluded that tRNA molecules are not able to approach the ribosome by ... -
Predicting the Release of Chemotherapeutics From the Core of Polymeric Micelles Using Ultrasound
Abdel-Hafez, Mamoun; Husseini, Ghaleb (IEEE Explore, 2015)In this paper, the estimation of acoustic drug release from micelles is addressed. The release is measured as a decrease in fluorescence once ultrasound is applied. Initially, a Kalman filter is used to fuse the drug ... -
Preliminary Modeling of Transfer RNA Kinetics in the Cytoplasm of Escherichia coli Bacteria
Piros, Sandor; Husseini, Ghaleb (American Scientific Publishers, 2010)Transfer RNAs (tRNAs) can recognize a specific amino acid from a possible pool of 20. Theyare able to transport these protein building-blocks to the ribosome, the site where amino acids assemble into protein chains. Accurate ... -
Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats
Pitt, William G.; Husseini, Ghaleb; Roeder, Beverly L.; Dickinson, David J.; Warden, David R.; Hartley, Jonathan M.; Jones, Peter W. (American Scientific Publishers, 2011)Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ... -
Rapid and convenient method for preparing masters for microcontact printing with 1–12 mm features
Zilch, Lloyd W.; Husseini, Ghaleb; Lua, Yit-Yian; V. Lee, MIchael; Gertsch, Kevin R,; Cannon, Bennion R.; Sevy, Eric T.; Asplund, Matthew C.; Woolley, Adam T.; Linford, Matthew R.; Perry, Robert M. (American Institute of Physics (AIP), 2004)Mechanical scribing can be employed to create surfaces with recessed features. Through replica molding elastomeric copies of these scribed surfaces are created that function as stamps for microcontact printing. It is shown ... -
Rapid separation of bacteria from blood – Chemical aspects
Alizadeh, Mahsa; Wood, Ryan L.; Buchanan, Clara M.; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Ravsten, Tanner V.; Husseini, Ghaleb; Hickey, Caroline L.; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)To rapidly diagnose infectious organisms causing blood sepsis, bacteria must be rapidly separated from blood, a very difficult process considering that concentrations of bacteria are many orders of magnitude lower than ... -
Rapid separation of very low concentrations of bacteria from blood
Buchanan, Clara M.; Wood, Ryan L.; Hoj, Taalin R.; Alizadeh, Mahsa; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Hickey, Caroline L.; Ravsten, Tanner V.; Husseini, Ghaleb; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)A rapid and accurate diagnosis of the species and antibiotic resistance of bacteria in septic blood is vital to increase survival rates of patients with bloodstream infections, particularly those with carbapenem-resistant ... -
Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration
Percival, Kelly M.; Paul, Vinod; Husseini, Ghaleb (MDPI, 2024)In exploring the challenges of bone repair and regeneration, this review evaluates the potential of bone tissue engineering (BTE) as a viable alternative to traditional methods, such as autografts and allografts. Key ... -
Recent Advances in Metal-Organic Frameworks as Anticancer Drug Delivery Systems: A Review
Karami, Abdollah; Mohamed, Omnia A.; Ahmed, Ahmed H.S; Husseini, Ghaleb; Sabouni, Rana (Bentham, 2021)Background: Metal-organic frameworks (MOFs), as attractive hybrid crystalline porous materials, are increasingly being investigated in biomedical applications owing to their exceptional properties, including high porosity, ... -
Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes
Hamidu, Aisha; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023)Cancer is one of the leading causes of death worldwide. Because each person’s cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly ...