Browsing by Author "61c3074c-7e2f-4e84-8097-640a3adbe003"
Now showing items 1-20 of 48
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Biodegradable Magnesium Alloys for Biomedical Implants: Properties, Challenges, and Surface Modifications with a Focus on Orthopedic Fixation Repair
Thomas, Kevin Koshy; Zafar, Mah Noor; Pitt, William G. (MDPI, 2023-12-19)Biomedical devices made from high-modulus and hardness materials play a critical role in enhancing the quality of life for people with bone-related ailments. While these materials have been successfully used in orthopedic ... -
Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound
Diaz de la Rosa, Mario A.; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2013)We have previously reported that ultrasonic drug release at 70 kHz was found to correlate with the presence of subharmonic emissions. No evidence of drug release or of the subharmonic emissions were detected in experiments ... -
Cytosolic Delivery of Doxorubicin from Liposomes to Multidrug-Resistant Cancer Cells via Vaporization of Perfluorocarbon Droplets
Williams, Jacob B; Buchanan, Clara M.; Husseini, Ghaleb; Pitt, William G. (MedCrave, 2017)A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. ... -
Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound
Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Dickinson, David J. (Elsevier, 2009)The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications ... -
Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery
Staples, Bryant J.; Pitt, William G.; Roeder, Beverly L.; Husseini, Ghaleb; Rajeev, Deepthi; Schaalje, G. Bruce (Elsevier, 2010)Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo ... -
DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Husseini, Ghaleb; El-Fayoumi, Refaat I.; O'Neill, Kim L.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2000)To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ... -
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Marin, Alexander; Sun, Hao; Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2002)The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ... -
Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
Tanbour, Rafeeq Kamal; Martins, Ana M.; Pitt, William G.; Husseini, Ghaleb (Bentham Science Publishers, 2016)Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ... -
Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment
AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (American Chemical Society, 2021)The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix ... -
Encapsulation and release of calcein from herceptin-conjugated eLiposomes
Zafar, Mah Noor; Pitt, William G.; Husseini, Ghaleb (Elsevier, 2024-03)Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side ... -
Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery
Radha, Remya; Paul, Vinod; Anjum, Shabana; Bouakaz, Ayache; Pitt, William G.; Husseini, Ghaleb (Nature, 2024)Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained ... -
Factors affecting acoustically triggered release of drugs from polymeric micelles
Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ... -
Factors affecting sedimentational separation of bacteria from blood
Pitt, William G.; Alizadeh, Mahsa; Blanco, Rae; Hunter, Alex K.; Bledsoe, Colin G.; McClellan, Daniel S.; Wood, Madison E.; Wood, Ryan L.; Ravsten, Tanner V.; Hickey, Caroline L.; Beard, William Cameron; Stepan, Jacob R.; Carter, Alexandra; Husseini, Ghaleb; Robison, Richard A.; Welling, Evelyn; Torgesen, Rebekah N.; Anderson, Clifton M. (American Institute of Chemical Engineers (AIChE), 2019)Rapid diagnosis of blood infections requires fast and efficient separation of bacteria from blood. We have developed spinning hollow disks that separate bacteria from blood cells via the differences in sedimentation ... -
Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (Elsevier, 2023)The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the ... -
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
Muniruzzaman, Md.; Marin, Alexander; Luo, Yi; Prestwich, Glenn D.; Pitt, William G.; Husseini, Ghaleb; Rapoport, Natalya Y. (Elsevier, 2002)The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ... -
Investigating the acoustic release of doxorubicin from targeted micelles
Husseini, Ghaleb; Velluto, Diana; Kherbeck, Laura; Pitt, William G.; Hubbell, Jeffrey A.; Christensen, Douglas A. (Elsevier, 2013)The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable ... -
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
Husseini, Ghaleb; Runyan, Christopher M.; Pitt, William G. (BioMed Central (BMC), 2002)Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ... -
Investigating the Release Mechanism of Calcein from eLiposomes at Higher Temperatures
Husseini, Ghaleb; Pitt, William G.; Williams, Jacob B; Javadi, Marjan (American Scientific Publishers, 2014)Numerous nanocarriers are currently being investigated as drug delivery vehicles for transporting chemotherapeutics to cancer cells. Our research group has recently synthesized a new generation of echogenic liposomes based ... -
Investigating the Stability of eLiposomes at Elevated Temperatures
Husseini, Ghaleb; Pitt, William G.; Javadi, Marjan (Sage Publishing, 2014)eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor ... -
Kinetics and thermodynamics of acoustic release of doxorubicin from non-stabilized polymeric micelles
Husseini, Ghaleb; Abouelnasr, Dana; Pitt, William G.; Assaleh, Khaled; Farahat, Lujein O.; Fahadi, Jalal (Elsevier, 2010)This paper studies the thermodynamic characteristics of ultrasound-activated release of Doxorubicin (Dox) from micelles. The release and re-encapsulation of Dox into Pluronic® P105 micelles was measured by recording the ...