Browsing by Author "61c3074c-7e2f-4e84-8097-640a3adbe003"

Now showing items 21-40 of 48

    • Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; AlAqqad, Emad O.; Al Mamary, Saif; Kadimati, Yaman; Al Baik, Abdullah; Pitt, William G. (Elsevier, 2011)
      Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of ...

    • The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound 

      AlSawaftah, Nour Majdi; Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2022)
      Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable ...

    • Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles 

      Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)
      The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...

    • Liposomes for the Treatment of Brain Cancer — A Review 

      Raju, Richu; Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-06-25)
      Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain ...

    • Mathematical modeling of microbubble cavitation at 70 kHz and the importance of the subharmonic in drug delivery from micelles 

      Diaz de la Rosa, Mario A.; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2013)
      In order to gain insight into the experimental observation of ultrasound-induced release of drugs from micelles, we modeled the dynamic oscillations of a 10-μm-diameter bubble insonated at 70 kHz. The Parlitz modification ...

    • Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model 

      Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G. (Adenine Press, 2007)
      This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test ...

    • Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible? 

      Pitt, William G.; Jack, Daniel R.; Husseini, Ghaleb; Memmott, Brett V. (American Scientific Publishers, 2012)
      Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ...

    • Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles 

      Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G.; Al-Mousa, Alaa Marwan Subhi (Elsevier, 2011)
      In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to ...

    • pH-Responsive Nanocarriers in Cancer Therapy 

      AlSawaftah, Nour Majdi; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they ...

    • Phase transitions of nanoemulsions using ultrasound: Experimental observations 

      Singh, Ram; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2012)
      The ultrasound-induced transformation of perfluorocarbon liquids to gases is of interest in the area of drug and gene delivery. In this study, three independent parameters (temperature, size, and perfluorocarbon species) ...

    • Phase transitions of perfluorocarbon nanoemulsion induced with ultrasound: A mathematical model 

      Pitt, William G.; Singh, Ram; Perez, Krystian X.; Husseini, Ghaleb; Jack, Daniel R. (Elsevier, 2013)
      While ultrasound has been used in many medical and industrial applications, only recently has research been done on phase transformations induced by ultrasound. This paper presents a numerical model and the predicted results ...

    • Photo-Induced Drug Release from Polymeric Micelles and Liposomes: Phototriggering Mechanisms in Drug-Delivery Systems 

      Salkho, Najla; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs ...

    • Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats 

      Pitt, William G.; Husseini, Ghaleb; Roeder, Beverly L.; Dickinson, David J.; Warden, David R.; Hartley, Jonathan M.; Jones, Peter W. (American Scientific Publishers, 2011)
      Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...

    • Rapid separation of bacteria from blood – Chemical aspects 

      Alizadeh, Mahsa; Wood, Ryan L.; Buchanan, Clara M.; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Ravsten, Tanner V.; Husseini, Ghaleb; Hickey, Caroline L.; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)
      To rapidly diagnose infectious organisms causing blood sepsis, bacteria must be rapidly separated from blood, a very difficult process considering that concentrations of bacteria are many orders of magnitude lower than ...

    • Rapid separation of very low concentrations of bacteria from blood 

      Buchanan, Clara M.; Wood, Ryan L.; Hoj, Taalin R.; Alizadeh, Mahsa; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Hickey, Caroline L.; Ravsten, Tanner V.; Husseini, Ghaleb; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)
      A rapid and accurate diagnosis of the species and antibiotic resistance of bacteria in septic blood is vital to increase survival rates of patients with bloodstream infections, particularly those with carbapenem-resistant ...

    • Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes 

      Hamidu, Aisha; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023)
      Cancer is one of the leading causes of death worldwide. Because each person’s cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly ...

    • Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)
      Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...

    • A Review on Membrane Fouling Prediction Using Artificial Neural Networks (ANNs) 

      Abuwatfa, Waad Hussein; AlSawaftah, Nour Majdi; Darwish, Naif A.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-07-24)
      Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of ...

    • Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats 

      Staples, Bryant J.; Roeder, Beverly L.; Husseini, Ghaleb; Badamjav, Odgerel; Schaalje, G. Bruce; Pitt, William G. (Springer, 2009)
      Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...

    • Scaffold‑based 3D cell culture models in cancer research 

      Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (Springer Nature, 2024)
      Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown ...