Browsing by Author "796c0acb-7161-4e53-9476-8b7422f1949e"

Now showing items 1-12 of 12

    • The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles 

      Husseini, Ghaleb; O'Neill, Kim L.; Pitt, William G. (Adenine Press, 2005)
      This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...

    • Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models 

      Stevenson-Abouelnasr, Dana; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2006)
      The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the ...

    • Kinetics of Ultrasonic Drug Delivery from Targeted Micelles 

      Husseini, Ghaleb; Kherbeck, Laura; Pitt, William G.; Christensen, Douglas A.; Velluto, Diana (American Scientific Publishers, 2015)
      To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This ...

    • Micelles and nanoparticles for ultrasonic drug and gene delivery 

      Husseini, Ghaleb; Pitt, William G. (Elsevier, 2008)
      Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ...

    • Over-Pressure Suppresses Ultrasonic-Induced Drug Uptake 

      Stringham, S. Briant; Viskovska, Maria A.; Richardson, Eric S.; Ohmine, Seiga; Husseini, Ghaleb; Murray, Byron K.; Pitt, William G. (Elseviser, 2008)
      Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent ...

    • Rapid Separation of Bacteria from Blood - Review and Outlook 

      Pitt, William G.; Alizadeh, Mahsa; Husseini, Ghaleb; McClellan, Daniel S.; Buchanan, Clara M.; Bledsoe, Colin G.; Blanco, Rae; Melville, Madison; Hunter, Alex K.; Robison, Richard A.; Roeder, Beverly L. (American Institute of Chemical Engineers (AIChE), 2016)
      The high morbidity and mortality rate of bloodstream infections involving antibiotic‐resistant bacteria necessitate a rapid identification of the infectious organism and its resistance profile. Traditional methods based ...

    • The role of cavitation in acoustically activated drug delivery 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Richardson, Eric S.; Christensen, Douglas A.; Pitt, William G. (Elsevier Science Direct, 2005)
      Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...

    • Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment 

      Husseini, Ghaleb; Pitt, William G. (Wiley InterSciences, 2008)
      The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...

    • Ultrasonically triggered drug delivery: Breaking the barrier 

      Husseini, Ghaleb; Pitt, William G.; Martins, Ana M. (Elsevier, 2014)
      The adverse side-effects of chemotherapy can be minimized by delivering the therapeutics in time and space to only the desired target site. Ultrasound offers one fairly non-invasive method of accomplishing such precise ...

    • Ultrasound in drug and gene delivery 

      Pitt, William G.; Husseini, Ghaleb (Elsevier, 2008)
      In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...

    • Ultrasound-responsive Nanocarriers in Cancer Treatment: a review 

      Awad, Nahid S.; Paul, Vinod; Haar, Gail ter; Allen, Theresa M.; Pitt, William G.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)
      The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...

    • Ultrasound-triggered Release from Micelles 

      Pitt, William G.; Husseini, Ghaleb; Kherbeck, Laura (Royal Society of Chemistry, 2013)