Now showing items 21-37 of 37

    • pH-Responsive Nanocarriers in Cancer Therapy 

      AlSawaftah, Nour Majdi; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they ...
    • Photo-Induced Drug Release from Polymeric Micelles and Liposomes: Phototriggering Mechanisms in Drug-Delivery Systems 

      Salkho, Najla; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs ...
    • Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy 

      Al Bostami, Rouba D.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022-08)
      Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient ...
    • Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes 

      Hamidu, Aisha; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023)
      Cancer is one of the leading causes of death worldwide. Because each person’s cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly ...
    • Redox-Responsive Drug Delivery Systems: A Chemical Perspective 

      Abed, Heba; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022)
      With the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redoxresponsive drug delivery systems (DDSs) ...
    • A Review on Membrane Biofouling: Prediction, Characterization, and Mitigation 

      AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Darwish, Naif; Husseini, Ghaleb (MDPI, 2022-12-15)
      Water scarcity is an increasing problem on every continent, which instigated the search for novel ways to provide clean water suitable for human use; one such way is desalination. Desalination refers to the process of ...
    • A Review on Membrane Fouling Prediction Using Artificial Neural Networks (ANNs) 

      Abuwatfa, Waad Hussein; AlSawaftah, Nour Majdi; Darwish, Naif A.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-07-24)
      Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of ...
    • Scaffold‑based 3D cell culture models in cancer research 

      Abuwatfa, Waad Hussein; Pitt, William G.; Husseini, Ghaleb (Springer Nature, 2024)
      Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown ...
    • Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems 

      Abuwatfa, Waad Hussein; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven ...
    • Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review 

      Kawak, Paul S.; AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (MDPI, 2026-08-26)
      Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective ...
    • Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells 

      AlSawaftah, Nour Majdi; Awad, Nahid S.; Paul, Vinod; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (Nature, 2021)
      Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency ...
    • Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment 

      Awad, Nahid S.; Salkho, Najla; Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2023)
      Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. ...
    • Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review 

      Bahutair, Wafa N.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022)
      Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems ...
    • Ultrasound-Mediated Cancer Therapeutics Delivery using Micelles and Liposomes: A Review 

      Mukhopadhyay, Debasmita; Sano, Catherine; AlSawaftah, Nour Majdi; Paul, Vinod; El-Awadi, Rafat; Husseini, Ghaleb (Bentham Science Publisher, 2021)
      Nanoparticles have proven promising as cancer theranostic tools. Nanoparticles are selective in nature, have reduced toxicity, and controllable drug release patterns making them ideal carriers for anticancer drugs. Numerous ...
    • Ultrasound-responsive Nanocarriers in Cancer Treatment: a review 

      Awad, Nahid S.; Paul, Vinod; Haar, Gail ter; Allen, Theresa M.; Pitt, William G.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)
      The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...
    • Ultrasound-triggered Immunotherapy for Cancer Treatment: An Update 

      Mukhopadhyay, Debasmita; Ahmed, Amal Elsadig Elamir; Sano, Catherine; Awad, Nahid S.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Bentham, 2021)
    • Ultrasound‑triggered herceptin liposomes for breast cancer therapy 

      Elamir, Amal; Ajith, Saniha Aysha; AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Mukhopadhyay, Debasmita; Paul, Vinod; Al-Sayah, Mohammad; Awad, Nahid S.; Husseini, Ghaleb (Nature, 2021)
      The functionalization of liposomes with monoclonal antibodies is a potential strategy to increase the specificity of liposomes and reduce the side-effects associated with chemotherapeutic agents. The active targeting of ...