Now showing items 1-11 of 11

    • Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review 

      Al Sharabati, Miral Osama Yacoub; Sabouni, Rana; Husseini, Ghaleb (MDPI, 2021)
      Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and ...
    • Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment 

      AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (American Chemical Society, 2021)
      The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix ...
    • Effect of High-Frequency Ultrasound on Targeted Liposomes 

      AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)
      Delivering highly toxic drugs inside a safe carrier to tumors while achieving a controlled and effective drug release at the targeted sites represents an attractive approach to enhance drug efficiency while reducing its ...
    • In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes 

      Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Farooq, Afifa; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)
      Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable ...
    • The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound 

      AlSawaftah, Nour Majdi; Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2022)
      Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable ...
    • Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review 

      AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (IEEE, 2021)
      Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. ...
    • Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells 

      AlSawaftah, Nour Majdi; Awad, Nahid S.; Paul, Vinod; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (Nature, 2021)
      Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency ...
    • Ultrasound-Mediated Cancer Therapeutics Delivery using Micelles and Liposomes: A Review 

      Mukhopadhyay, Debasmita; Sano, Catherine; AlSawaftah, Nour Majdi; Paul, Vinod; El-Awadi, Rafat; Husseini, Ghaleb (Bentham Science Publisher, 2021)
      Nanoparticles have proven promising as cancer theranostic tools. Nanoparticles are selective in nature, have reduced toxicity, and controllable drug release patterns making them ideal carriers for anticancer drugs. Numerous ...
    • Ultrasound-responsive Nanocarriers in Cancer Treatment: a review 

      Awad, Nahid S.; Paul, Vinod; Haar, Gail ter; Allen, Theresa M.; Pitt, William G.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)
      The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...
    • Ultrasound-triggered Immunotherapy for Cancer Treatment: An Update 

      Mukhopadhyay, Debasmita; Ahmed, Amal Elsadig Elamir; Sano, Catherine; Awad, Nahid S.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Bentham, 2021)
    • Ultrasound‑triggered herceptin liposomes for breast cancer therapy 

      Elamir, Amal; Ajith, Saniha Aysha; AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Mukhopadhyay, Debasmita; Paul, Vinod; Al-Sayah, Mohammad; Awad, Nahid S.; Husseini, Ghaleb (Nature, 2021)
      The functionalization of liposomes with monoclonal antibodies is a potential strategy to increase the specificity of liposomes and reduce the side-effects associated with chemotherapeutic agents. The active targeting of ...