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Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles
(2012-06)
To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasound. This thesis reports ...
Ultrasound Triggered Release of Estrone- Targeted Liposomes
(2017-05)
The fight against cancer has proven to be a lengthy one. Conventional treatment of cancer usually involves chemotherapy, a therapy known for its detrimental side effects. Doxorubicin, a cytotoxic anthracycline antibiotic, ...
Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound
(American Scientific Publishers, 2007)
Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
Cytosolic Delivery of Doxorubicin from Liposomes to Multidrug-Resistant Cancer Cells via Vaporization of Perfluorocarbon Droplets
(MedCrave, 2017)
A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. ...
Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers
(American Scientific Publishers, 2015)
Folic acid (FA) is one of the most utilized moieties in active (ligand) drug delivery. The folate receptor is widely expressed on the surface of several cell lines and tumors; including ovarian, brain, kidney, breast, and ...
The role of cavitation in acoustically activated drug delivery
(Elsevier Science Direct, 2005)
Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
(Elsevier, 2002)
The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ...
Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles
(Elsevier, 2011)
In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to ...
Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model
(Adenine Press, 2007)
This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test ...
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
(Elsevier, 2001)
The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...