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Rapid separation of bacteria from blood – Chemical aspects
(Elsevier, 2017)
To rapidly diagnose infectious organisms causing blood sepsis, bacteria must be rapidly separated from blood, a very difficult process considering that concentrations of bacteria are many orders of magnitude lower than ...
Ultrasound-Induced Calcein Release From eLiposomes
(Elsevier, 2012)
Ultrasound is explored as a method of inducing the release of encapsulated materials from eLiposomes, defined as liposomes containing emulsion droplets. Emulsions were formed using perfluorohexane and perfluoropentane. ...
Factors affecting sedimentational separation of bacteria from blood
(American Institute of Chemical Engineers (AIChE), 2019)
Rapid diagnosis of blood infections requires fast and efficient separation of bacteria from blood. We have developed spinning hollow disks that separate bacteria from blood cells via the differences in sedimentation ...
Cytosolic Delivery of Doxorubicin from Liposomes to Multidrug-Resistant Cancer Cells via Vaporization of Perfluorocarbon Droplets
(MedCrave, 2017)
A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. ...
Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible?
(American Scientific Publishers, 2012)
Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ...
Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
(Bentham Science Publishers, 2016)
Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ...
Kinetics and thermodynamics of acoustic release of doxorubicin from non-stabilized polymeric micelles
(Elsevier, 2010)
This paper studies the thermodynamic characteristics of ultrasound-activated release of Doxorubicin (Dox) from micelles. The release and re-encapsulation of Dox into Pluronic® P105 micelles was measured by recording the ...
Phase transitions of perfluorocarbon nanoemulsion induced with ultrasound: A mathematical model
(Elsevier, 2013)
While ultrasound has been used in many medical and industrial applications, only recently has research been done on phase transformations induced by ultrasound. This paper presents a numerical model and the predicted results ...
Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles
(Elsevier, 2011)
In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to ...
Investigating the Stability of eLiposomes at Elevated Temperatures
(Sage Publishing, 2014)
eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor ...