Now showing items 1-5 of 5
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ...
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...
DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ...
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
(BioMed Central (BMC), 2002)
Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ...