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Liposomal drug release using ultrasound and modeling release dynamics for model predictive controller design
(2015-06)
Chemotherapy is widely used for cancer treatment; however, it causes unwanted side effects in patients such as fatigue, weight loss, pain, hair fall and nausea. Those side effects are due to the fact that most of the ...
Modeling and Bias-Robust Estimation of the Acoustic Release of Chemotherapeutics from Liposomes
(American Scientific Publishers, 2019)
This paper models the acoustic drug release of chemotherapeutics from liposomes using a kinetic model that accounts for systematic biases affecting the drug delivery process. An optimal stochastic filter is then proposed ...
Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment
(Wiley InterSciences, 2008)
The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...
Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
(Bentham Science Publishers, 2016)
Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ...
Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release
(Bentham Science Publishers, 2018)
Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering ...
Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes
(American Scientific Publishers, 2019)
Typical methods used in cancer treatment, including chemotherapy, are debilitating because of the various adverse side effects experienced by cancer patients. The free drug injected into the patient at given doses affects ...
Predicting the Release of Chemotherapeutics From the Core of Polymeric Micelles Using Ultrasound
(IEEE Explore, 2015)
In this paper, the estimation of acoustic drug release from micelles is addressed. The release is measured as a decrease in fluorescence once ultrasound is applied. Initially, a Kalman filter is used to fuse the drug ...
Ultrasound-responsive Nanocarriers in Cancer Treatment: a review
(American Chemical Society, 2021)
The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...
A Novel Cancer Treatment Platform Utilizing HER2-Immunoliposomes and Ultrasound
(2020-05)
Cancer is defined as the uncontrolled growth of cells in the body. It is one of the leading causes of death worldwide. One of the most common approaches to destroy cancer cells is via chemotherapy treatment, in which ...