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Now showing items 31-40 of 54
The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles
(Adenine Press, 2005)
This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...
Mathematical modeling of microbubble cavitation at 70 kHz and the importance of the subharmonic in drug delivery from micelles
(Elsevier, 2013)
In order to gain insight into the experimental observation of ultrasound-induced release of drugs from micelles, we modeled the dynamic oscillations of a 10-μm-diameter bubble insonated at 70 kHz. The Parlitz modification ...
Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles
(SAGE Publications, 2009)
We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the ...
Ultrasound in drug and gene delivery
(Elsevier, 2008)
In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...
Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats
(American Scientific Publishers, 2011)
Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...
Investigating the acoustic release of doxorubicin from targeted micelles
(Elsevier, 2013)
The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable ...
Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound
(Elsevier, 2013)
We have previously reported that ultrasonic drug release at 70 kHz was found to correlate with the presence of subharmonic emissions. No evidence of drug release or of the subharmonic emissions were detected in experiments ...
Factors affecting acoustically triggered release of drugs from polymeric micelles
(Elsevier, 2000)
A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...
Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats
(Springer, 2009)
Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...
Rapid separation of very low concentrations of bacteria from blood
(Elsevier, 2017)
A rapid and accurate diagnosis of the species and antibiotic resistance of bacteria in septic blood is vital to increase survival rates of patients with bloodstream infections, particularly those with carbapenem-resistant ...