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dc.contributor.authorHusseini, Ghaleb
dc.contributor.authorMyrup, Gregg D.
dc.contributor.authorPitt, William G.
dc.contributor.authorChristensen, Douglas A.
dc.contributor.authorRapoport, Natalya Y.
dc.date.accessioned2020-12-17T06:03:53Z
dc.date.available2020-12-17T06:03:53Z
dc.date.issued2000
dc.identifier.citationHusseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2000). Factors affecting acoustically triggered release of drugs from polymeric micelles. Journal of Controlled Release, 69(1), 43–52. https://doi.org/10.1016/s0168-3659(00)00278-9en_US
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/11073/19828
dc.description.abstractA custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency range of 20 to 90 kHz. The measurements were based on the decrease in fluorescence intensity when drug was transferred from the micelle core to the aqueous environment. Two fluorescent drugs were used: doxorubicin (DOX) and its paramagnetic analogue, ruboxyl (Rb). Pluronic P-105 at various concentrations in aqueous solutions was used as a micelle-forming polymer. Drug release was most efficient at 20-kHz ultrasound and dropped with increasing ultrasonic frequency despite much higher power densities. These data suggest an important role of transient cavitation in drug release. The release of DOX was higher than that of Rb due to stronger interaction and deeper insertion of Rb into the core of the micelles. Drug release was higher at lower Pluronic concentrations, which presumably resulted from higher local drug concentrations in the core of Pluronic micelles when the number of micelles was low. At constant frequency, drug release increased with increasing power density. At constant power density and for pulse duration longer than 0.1 s, peak release under pulsed ultrasound was the same as stationary release under CW ultrasound. Released drug was quickly re-encapsulated between the pulses of ultrasound, which suggests that upon leaving the sonicated volume, the non-extravasated and non-internalized drug would circulate in the encapsulated form, thus preventing unwanted drug interactions with normal tissues.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.urihttps://doi.org/10.1016/S0168-3659(00)00278-9en_US
dc.subjectPolymeric micellesen_US
dc.subjectTriggered releaseen_US
dc.subjectUltrasounden_US
dc.subjectPluronicen_US
dc.subjectMicellizationen_US
dc.subjectDrug deliveryen_US
dc.subjectDoxorubicinen_US
dc.subjectRuboxylen_US
dc.titleFactors affecting acoustically triggered release of drugs from polymeric micellesen_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePostprinten_US
dc.identifier.doi10.1016/S0168-3659(00)00278-9


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