dc.contributor.author | Husseini, Ghaleb | |
dc.contributor.author | O'Neill, Kim L. | |
dc.contributor.author | Pitt, William G. | |
dc.date.accessioned | 2021-01-14T06:59:24Z | |
dc.date.available | 2021-01-14T06:59:24Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Ghaleb A. Husseini, Kim L. O'Neill, William G. Pitt, The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles, Technology in Cancer Research & Treatment, vol. 4, 6: pp. 707-711. | en_US |
dc.identifier.issn | 1533-0346 | |
dc.identifier.uri | http://hdl.handle.net/11073/21271 | |
dc.description.abstract | This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 minutes. They were then lysed, electrophorised, stained using propidium iodide, and their DNA profile captured using a fluorescent microscope. The gradual DNA damage observed and the comet tails captured after one and two hours of insonation suggest that the mode of cell killing is apoptosis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Adenine Press | en_US |
dc.relation.uri | https://doi.org/10.1177/153303460500400616 | en_US |
dc.subject | Micellar drug delivery | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | Comet Assay | en_US |
dc.subject | Ultrasound | en_US |
dc.subject | Apoptosis | en_US |
dc.title | The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles | en_US |
dc.type | Peer-Reviewed | en_US |
dc.type | Article | en_US |
dc.type | Postprint | en_US |
dc.identifier.doi | 10.1177/153303460500400616 | |