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dc.contributor.authorHusseini, Ghaleb
dc.contributor.authorPitt, William G.
dc.date.accessioned2021-01-14T08:12:26Z
dc.date.available2021-01-14T08:12:26Z
dc.date.issued2008
dc.identifier.citationGhaleb A. Husseini, William G. Pitt, Micelles and nanoparticles for ultrasonic drug and gene delivery, Advanced Drug Delivery Reviews, Volume 60, Issue 10, 2008, Pages 1137-1152, ISSN 0169-409X, https://doi.org/10.1016/j.addr.2008.03.008.en_US
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/11073/21274
dc.description.abstractDrug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body. Ultrasound, traditionally used in diagnostic medicine, is finding a place in drug delivery in connection with these nanoparticles. In addition to their non-invasive nature and the fact that they can be focused on targeted tissues, acoustic waves have been credited with releasing pharmacological agents from nanocarriers, as well as rendering cell membranes more permeable. In this article, we summarize new technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery. Ultrasonic drug delivery from micelles usually employs polyether block copolymers and has been found effective in vivo for treating tumors. Ultrasound releases drug from micelles, most probably via shear stress and shock waves from the collapse of cavitation bubbles. Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. The small packaging allows nanoparticles to extravasate into tumor tissues. Ultrasonic drug and gene delivery from nanocarriers has tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly non-invasive means.en_US
dc.description.sponsorshipCollege of Engineeringen_US
dc.description.sponsorshipDepartment of Chemical Engineeringen_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesAmerican University of Sharjah Faculty Worken_US
dc.relation.urihttps://doi.org/10.1016/j.addr.2008.03.008en_US
dc.subjectTargeted deliveryen_US
dc.subjectPolymeric micellesen_US
dc.subjectThermo-responsive polymersen_US
dc.subjectUltrasounden_US
dc.subjectNon-viral gene transfectionen_US
dc.subjectDrug deliveryen_US
dc.subjectNanoemulsionsen_US
dc.subjectSolid nanoparticlesen_US
dc.subjectLiposomesen_US
dc.titleMicelles and nanoparticles for ultrasonic drug and gene deliveryen_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePostprinten_US
dc.identifier.doi10.1016/j.addr.2008.03.008


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