dc.contributor.author | Elkhodiry, Mohamed A. | |
dc.contributor.author | Husseini, Ghaleb | |
dc.contributor.author | Velluto, Diana | |
dc.date.accessioned | 2021-03-07T06:41:22Z | |
dc.date.available | 2021-03-07T06:41:22Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Elkhodiry MA, Husseini GA, Velluto D. Targeting the Folate Receptor: Effects of Conjugating Folic Acid to DOX Loaded Polymeric Micelles. Anticancer Agents Med Chem. 2016;16(10):1275-80. doi: 10.2174/1871520616666160219161600. PMID: 26899187. | en_US |
dc.identifier.issn | 1275-1280 | |
dc.identifier.uri | http://hdl.handle.net/11073/21344 | |
dc.description.abstract | In this paper, we report on a potential cancer drug delivery system that utilizes the ligand targeting of the folate receptor. Our drug delivery system consists of Pluronic-P105 micelles, targeted with folic acid moieties. A melanoma folate positive (FR+) (B16-F10), and a fibroblast folate negative (FR-) (NIH-3T3) cell lines are used to compare the cellular accumulation of a chemotherapeutic drug (Doxorubicin) when the delivery is mediated by folated Pluronic P105 micelles. In order to obtain a proper comparison, we corrected for the quenching of Doxorubicin by folic acid molecules and illustrated the significant effect of quenching on the analysis of similar systems. Results show an 80% increase in the accumulation of the antineoplastic agent in the FR+ cell line, when compared to the FR- cell line, thus providing evidence that the efficacy of Pluronic micelles, as drug delivery vehicles, can be enhanced via folic acid targeting. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.relation.uri | https://doi.org/10.2174/1871520616666160219161600 | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | Micelles | en_US |
dc.subject | Folate | en_US |
dc.subject | Active targeting | en_US |
dc.subject | Quenching | en_US |
dc.subject | B16-F10 | en_US |
dc.subject | Melanoma | en_US |
dc.title | Targeting the Folate Receptor: Effects of Conjugating Folic Acid to DOX Loaded Polymeric Micelles | en_US |
dc.type | Peer-Reviewed | en_US |
dc.type | Article | en_US |
dc.type | Postprint | en_US |
dc.identifier.doi | 10.2174/1871520616666160219161600 | |