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dc.contributor.authorAlSawaftah, Nour Majdi
dc.contributor.authorAwad, Nahid S.
dc.contributor.authorPitt, William G.
dc.contributor.authorHusseini, Ghaleb
dc.date.accessioned2022-02-28T07:13:06Z
dc.date.available2022-02-28T07:13:06Z
dc.date.issued2022
dc.identifier.citationAlSawaftah, N.M.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. pH-Responsive Nanocarriers in Cancer Therapy. Polymers 2022, 14, 936. https://doi.org/10.3390/polym14050936en_US
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/11073/21643
dc.description.abstractA number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy.en_US
dc.description.sponsorshipDana Gas Endowed Chair for Chemical Engineeringen_US
dc.description.sponsorshipAmerican University of Sharjahen_US
dc.description.sponsorshipSheikh Hamdan Award for Medical Sciencesen_US
dc.description.sponsorshipFriends of Cancer Patienten_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.urihttps://doi.org/10.3390/polym14050936en_US
dc.subjectNanoparticlesen_US
dc.subjectpHen_US
dc.subjectDrug Deliveryen_US
dc.subjectCanceren_US
dc.titlepH-Responsive Nanocarriers in Cancer Therapyen_US
dc.typeArticleen_US
dc.typePeer-Revieweden_US
dc.typePublished versionen_US
dc.identifier.doi10.3390/polym14050936


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