Show simple item record

dc.contributor.authorDalibalta, Sarah
dc.contributor.authorMajdalawieh, Amin
dc.contributor.authorManjikian, Herak
dc.date.accessioned2022-10-25T05:33:19Z
dc.date.available2022-10-25T05:33:19Z
dc.date.issued2020
dc.identifier.citationDalibalta S, Majdalawieh A, Manjikian H. (2020) Health benefits of sesamin on cardiovascular disease and its associated risk factors. Saudi Pharmaceutical Journal 28(10):1276-1289. https://doi.org/10.1016/j.jsps.2020.08.018.en_US
dc.identifier.issn1319-0164
dc.identifier.urihttp://hdl.handle.net/11073/25044
dc.description.abstractSesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro, and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.en_US
dc.description.sponsorshipAmerican University of Sharjahen_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.urihttps://doi.org/10.1016/j.jsps.2020.08.018en_US
dc.subjectSesaminen_US
dc.subjectCVDen_US
dc.subjectCardiovascular diseases (CVDs)en_US
dc.subjectHypertensionen_US
dc.subjectAtherosclerosisen_US
dc.subjectThrombosisen_US
dc.subjectDiabetesen_US
dc.subjectObesityen_US
dc.titleHealth benefits of sesamin on cardiovascular disease and its associated risk factorsen_US
dc.typeArticleen_US
dc.typePeer-Revieweden_US
dc.typePublished versionen_US
dc.identifier.doi10.1016/j.jsps.2020.08.018


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record