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dc.contributor.authorNarasimhan, Srinivasan
dc.contributor.authorMaheshwaran, Shanmugam
dc.contributor.authorAbu-Yousef, Imad
dc.contributor.authorMajdalawieh, Amin
dc.contributor.authorRethavathi, Janarthanam
dc.contributor.authorDas, Prince Edwin
dc.contributor.authorPoltronieri, Palmiro
dc.date.accessioned2022-10-25T07:15:48Z
dc.date.available2022-10-25T07:15:48Z
dc.date.issued2017
dc.identifier.citationNarasimhan, S.; Maheshwaran, S.; Abu-Yousef, I.A.; Majdalawieh, A.F.; Rethavathi, J.; Das, P.E.; Poltronieri, P. Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana. Molecules 2017, 22, 275. https://doi.org/10.3390/molecules22020275 [This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design]en_US
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11073/25048
dc.description.abstractThe microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.en_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.urihttps://doi.org/10.3390/molecules22020275en_US
dc.subjectSemi-synthetic modificationen_US
dc.subjectBiomedical deviceen_US
dc.subjectTextilesen_US
dc.subjectPackagingen_US
dc.subjectAnti-fungalen_US
dc.subjectAnti-bacterialen_US
dc.subjectα-Mangostinen_US
dc.titleAnti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostanaen_US
dc.typeArticleen_US
dc.typePeer-Revieweden_US
dc.typePublished versionen_US
dc.identifier.doi10.3390/molecules22020275


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