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dc.contributor.authorMajdalawieh, Amin
dc.contributor.authorRo, Hyo-Sung
dc.date.accessioned2022-10-31T09:39:55Z
dc.date.available2022-10-31T09:39:55Z
dc.date.issued2010
dc.identifier.citationAmin Majdalawieh, Hyo-Sung Ro, "Regulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages", Mediators of Inflammation, vol. 2010, Article ID 823821, 27 pages, 2010. https://doi.org/10.1155/2010/823821en_US
dc.identifier.issn1466-1861
dc.identifier.urihttp://hdl.handle.net/11073/25059
dc.description.abstractNF-𝜅B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-𝜅B in inflammation and atherosclerosis and the regulation of the NF-𝜅B signaling pathway are summarized. The structure, function, and regulation of the NF-𝜅B inhibitors, I𝜅Bα and I𝜅Bβ , are reviewed. The regulation of NF-𝜅B activity by glucocorticoid receptor (GR) signaling and I𝜅Bα sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-𝜅B transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-𝜅B via physical interaction with I𝜅Bα and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified I𝜅Bα-interacting proteins play in NF-𝜅B signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.en_US
dc.language.isoen_USen_US
dc.publisherHindawien_US
dc.relation.urihttps://doi.org/10.1155/2010/823821en_US
dc.titleRegulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophagesen_US
dc.typeArticleen_US
dc.typePeer-Revieweden_US
dc.typePublished versionen_US
dc.identifier.doi10.1155/2010/823821


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