Knowledge management (KM) plays a key role in the success of several enterprise systems, such as supply chain management (SCM). This paper discusses knowledge-enabled supply chain management (K-SCM) as it enhances the organizations’ expertise in SCM. We propose a framework that integrates KM processes with SCM components. We developed an audit methodology that can be performed to assess the organization’s readiness in K-SCM. The developed framework consists of KM dimensions and Supply Chain Operations Reference (SCOR) components. The proposed audit methodology is subsequently illustrated through a case of a manufacturing company based in the United Arab Emirates (UAE). The paper concludes with implications for managerial practice and future research, with a special focus on sustainable SCM.