Browsing College of Arts and Sciences (CAS) by Author "7e042ced-f6d2-44bd-a388-b1e873093621"
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Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
Bogachev, Oleg; Majdalawieh, Amin; Pan, Xuefang; Zhang, Lei; Ro, Hyo-Sung (Springer Nature, 2011)Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipocyte ... -
Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-κB via IκBα Negative Regulation
Majdalawieh, Amin; Zhang, Lei; Ro, Hyo-Sung (The American Society for Cell Biology, 2007)Nuclear factor κB (NF-κB) subunits comprise a family of eukaryotic transcription factors that are critically involved in cell proliferation, inflammation, and apoptosis. Under basal conditions, NF-κB subunits are kept under ... -
AEBP1 is a Novel Oncogene: Mechanisms of Action and Signaling Pathways
Majdalawieh, Amin; Massri, Mariam; Ro, Hyo-Sung (Hindawi, 2020)Adipocyte enhancer-binding protein 1 (AEBP1) is a transcriptional repressor involved in the regulation of critical biological processes including adipogenesis, mammary gland development, inflammation, macrophage cholesterol ... -
Analysis of macro and micro elemental composition of different extracts and finished products of the medicinal Herb – Terminalia bellirica
Gunasekar, Conjeevaram J.; Abu-Yousef, Imad; Narasimhan, Srinivasan; Majdalawieh, Amin (PKP, 2019)Terminalina bellirica is considered to be a sacred plant with five distinctive tastes (sweet, sour, salty, bitter, and pungent). It stimulates the proper functioning of the digestive system, sensory organs and it is very ... -
Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana
Narasimhan, Srinivasan; Maheshwaran, Shanmugam; Abu-Yousef, Imad; Majdalawieh, Amin; Rethavathi, Janarthanam; Das, Prince Edwin; Poltronieri, Palmiro (MDPI, 2017)The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs ... -
Efficient and simple protocol employing borohydride systems to design a selective osthol-zirconium (OST-Zr) library from potential natural products
Viswanathan, Radhakrishnan; Abu-Yousef, Imad; Majdalawieh, Amin; Das, Prince Edwin; Narasimhan, Srinivasan (PKP, 2016)“Drug likeness” of a molecule is the prime criterion for a molecule to exhibit the desired pharmaceutical activity. A pharmacophore, which describes molecular features that are necessary for molecular recognition of a ... -
Evaluation of the interaction potential of synthetic ethylene glycol compounds with nuclear Factor κB
Narasimhan, Srinivasan; Majdalawieh, Amin; Abu-Yousef, Imad; Shanmugarajan, Dhivya; Ramasubramanian, Vishvanathan (PKP, 2013)In the last three decades, nuclear factor κB (NF-κB) has been the focus of many researchers who are interested in understanding the various molecular mechanisms involved in inflammatory diseases and cancer. Interference ... -
Green Synthesis of Encapsulated Copper Nanoparticles Using a Hydroalcoholic Extract of Moringa oleifera Leaves and Assessment of Their Antioxidant and Antimicrobial Activities
Das, Prince Edwin; Abu-Yousef, Imad; Majdalawieh, Amin; Narasimhan, Srinivasan; Poltronieri, Palmiro (MDPI, 2020)The synthesis of metal nanoparticles using plant extracts is a very promising method in green synthesis. The medicinal value of Moringa oleifera leaves and the antimicrobial activity of metallic copper were combined in the ... -
Health benefits of sesamin on cardiovascular disease and its associated risk factors
Dalibalta, Sarah; Majdalawieh, Amin; Manjikian, Herak (Elsevier, 2020)Sesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation ... -
Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19
Majdalawieh, Amin; Yousef, Sarah M.; Abu-Yousef, Imad; Nasrallah, Gheyath K. (IMR Press, 2022)Natural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory ... -
Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice
Zhang, Lei; Reidy, Shannon P.; Bogachev, Oleg; Hall, Brian K.; Majdalawieh, Amin; Ro, Hyo-Sung (Public Library of Science, 2011)Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell ... -
Novel algorithms for accurate DNA base-calling
Mohammed, Omniyah Gul; Assaleh, Khaled; Husseini, Ghaleb; Majdalawieh, Amin (Scientific Research Publishing, 2013)The ability to decipher the genetic code of different species would lead to significant future scientific achievements in important areas, including medicine and agriculture. The importance of DNA sequencing necessitated ... -
Objectively quantified physical activity and sedentary behaviour in a young UAE population
Dalibalta, Sarah; Majdalawieh, Amin; Yousef, Sarah M.; Gusbi, Mohammed; Wilson, Jason J; Tully, Mark A; Davison, Gareth (BMJ Publishing Group, 2021)Objectives There is a lack of public awareness of the importance of engaging in physical activity (PA) in the United Arab Emirates (UAE). Nearly 58% of the UAE adult population self-reports as being physically inactive ... -
Organ-specific toxicity evaluation of stearamidopropyl dimethylamine (SAPDMA) surfactant using zebrafish embryos
Al-Jamal, Ola; Al-Jighefee, Hadeel; Younes, Nadin; Abdin, Roba; Al‑Asmakh, Maha; Radwan, A. Bahgat; Sliem, Mostafa H.; Majdalawieh, Amin; Pintus, Gianfranco; Yassine, Hadi M.; Abdullah, Aboubakr M.; Da’as, Sahar I.; Nasrallah, Gheyath K. (Elsevier, 2020)Surfactants are widely used in the industry of detergents, household products, and cosmetics. SAPDMA is a cationic surfactant that is used mostly in cosmetics, conditioning agents and has recently gained attention as a ... -
Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19
Majdalawieh, Amin; Yousef, Sarah M.; Abu-Yousef, Imad (Medknow Publications, 2021)The ongoing outbreak of novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global health crisis. Development of a cure for this ... -
PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
Majdalawieh, Amin; Ro, Hyo-Sung (Sage, 2010)Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in ... -
Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing
Prabu, Durai; Majdalawieh, Amin; Abu-Yousef, Imad; Inbasekaran, Kadambari; Balasubramaniam, Tharani; Nallaperumal, Narayanan; Gunasekar, Conjeevaram J. (PKP, 2016)Introduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose ... -
Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive
Majdalawieh, Amin; Fayyad, Muneera W. (Elsevier, 2016)The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties ... -
Regulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages
Majdalawieh, Amin; Ro, Hyo-Sung (Hindawi, 2010)NF-𝜅B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-𝜅B in inflammation and atherosclerosis and the regulation of the NF-𝜅B ... -
The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
Zhang, Lei; Reidy, Shannon P.; Nicholson, Tara E.; Lee, Hyun-Jeong; Majdalawieh, Amin; Webber, Chris; Stewart, Bruce R.; Dolphin, Peter; Ro, Hyo-Sung (Springer Nature, 2005)Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP₁, which functions as a negative regulator ...