Browsing College of Engineering (CEN) by Title

Now showing items 357-376 of 386

    • Ultrasonic Drug Delivery Using Micelles and Liposomes 

      Martins, Ana M.; Ahmed, Salma E.; Vitor, Rute F.; Husseini, Ghaleb (Springer, 2016)
      The encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid ...

    • Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide 

      Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)
      Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...

    • Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment 

      Husseini, Ghaleb; Pitt, William G. (Wiley InterSciences, 2008)
      The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...

    • Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy 

      Awad, Nahid S.; Paul, Vinod; Al-Sayah, Mohammad; Husseini, Ghaleb (Taylor and Francis Online, 2019)
      Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release ...

    • Ultrasonically triggered drug delivery: Breaking the barrier 

      Husseini, Ghaleb; Pitt, William G.; Martins, Ana M. (Elsevier, 2014)
      The adverse side-effects of chemotherapy can be minimized by delivering the therapeutics in time and space to only the desired target site. Ultrasound offers one fairly non-invasive method of accomplishing such precise ...

    • Ultrasound in drug and gene delivery 

      Pitt, William G.; Husseini, Ghaleb (Elsevier, 2008)
      In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...

    • Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review 

      Bahutair, Wafa N.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022)
      Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems ...

    • Ultrasound-Induced Calcein Release From eLiposomes 

      Lattin, James R.; Pitt, William G.; Belnap, David M.; Husseini, Ghaleb (Elsevier, 2012)
      Ultrasound is explored as a method of inducing the release of encapsulated materials from eLiposomes, defined as liposomes containing emulsion droplets. Emulsions were formed using perfluorohexane and perfluoropentane. ...

    • Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study 

      Martins, Ana M.; Tanbour, Rafeeq Kamal; Elkhodiry, Mohamed A.; Husseini, Ghaleb (De Gruyter, 2016)
      The aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation ...

    • Ultrasound-Mediated Cancer Therapeutics Delivery using Micelles and Liposomes: A Review 

      Mukhopadhyay, Debasmita; Sano, Catherine; AlSawaftah, Nour Majdi; Paul, Vinod; El-Awadi, Rafat; Husseini, Ghaleb (Bentham Science Publisher, 2021)
      Nanoparticles have proven promising as cancer theranostic tools. Nanoparticles are selective in nature, have reduced toxicity, and controllable drug release patterns making them ideal carriers for anticancer drugs. Numerous ...

    • Ultrasound-Mediated Drug Delivery in Cancer Therapy: A Review 

      AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Scientific Publishers, 2020)
      The use of ultrasound as a medical diagnostic tool began in the 1940s. Ever since, the medical applications of ultrasound have included imaging, tumor ablation, and lithotripsy; however, an ever-increasing body of literature ...

    • Ultrasound-responsive Nanocarriers in Cancer Treatment: a review 

      Awad, Nahid S.; Paul, Vinod; Haar, Gail ter; Allen, Theresa M.; Pitt, William G.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)
      The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...

    • Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system 

      AlSawaftah, Nour Majdi; Paul, Vinod; Kosaji, Doua Jamal; Khabbaz, Leen; Awad, Nahid S.; Husseini, Ghaleb (Taylor & Francis, 2022)
      Targeted liposomes enable the delivery of encapsulated chemotherapeutics to tumours by targeting specific receptors overexpressed on the surfaces of cancer cells; this helps in reducing the systemic side effects associated ...

    • Ultrasound-triggered Immunotherapy for Cancer Treatment: An Update 

      Mukhopadhyay, Debasmita; Ahmed, Amal Elsadig Elamir; Sano, Catherine; Awad, Nahid S.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Bentham, 2021)

    • Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer 

      Awad, Nahid S.; Haider, Mohamed; Paul, Vinod; AlSawaftah, Nour Majdi; Jagal, Jayalakshmi; Pasricha, Renu; Husseini, Ghaleb (MDPI, 2021)
      Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their ...

    • Ultrasound-triggered Release from Micelles 

      Pitt, William G.; Husseini, Ghaleb; Kherbeck, Laura (Royal Society of Chemistry, 2013)

    • Ultrasound‑triggered herceptin liposomes for breast cancer therapy 

      Elamir, Amal; Ajith, Saniha Aysha; AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Mukhopadhyay, Debasmita; Paul, Vinod; Al-Sayah, Mohammad; Awad, Nahid S.; Husseini, Ghaleb (Nature, 2021)
      The functionalization of liposomes with monoclonal antibodies is a potential strategy to increase the specificity of liposomes and reduce the side-effects associated with chemotherapeutic agents. The active targeting of ...

    • A Unified Approach for Probability of Detection Evaluation over Generalised Fading Channels 

      El Ayadi, Moataz M. H.; Ismail, Mahmoud H.; Alhennawi, Husam R. (Institution of Engineering and Technology, 2016)
      In this paper, we revisit energy detection-based spectrum sensing cognitive radio systems operating over generalised fading channels. In particular, we derive closed-form exact expressions as well as lowand high-signal-to-noise ...

    • Up-to-date earthquake and focal mechanism solutions datasets for the assessment of seismic hazard in the vicinity of the United Arab Emirates 

      Sawires, Rashad; Pelaez, Jose A.; AlHamaydeh, Mohammad; Henares, Jesús (Elsevier, 2019)
      This article presents updated and unified Poissonian earthquake and focal mechanism catalogs for the United Arab Emirates and its surroundings. Data were compiled from different local, regional, and international sources. ...

    • Use of Aluminum Alloy Plates as Externally Bonded Shear Reinforcement for R/C Beams 

      Abdalla, Jamal; Abu-Obeidah, Adi Salman; Hawileh, Rami (Elsevier, 2019)
      Fiber Reinforced Polymers (FRP) and steel had proven to be very effective as externally bonded shear strengthening materials However, they both have their shortcomings. Recently developed high strength Aluminum Alloy (AA) ...