Browsing Department of Chemical and Biological Engineering by Author "2e6c57f9-e9be-4279-9ded-1ea3b257620c"
Now showing items 1-20 of 27
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Carbohydrate-Functionalized Liposomes In Cancer Therapy
AlSawaftah, Nour Majdi; Abusamra, Rand Hasan; Husseini, Ghaleb (Bentham Science, 2020)Existing cancer treatments are often accompanied by adverse side effects that can greatly reduce the quality of life of cancer patients; this sets the platform for the development and application of nanocarrier-based ... -
A Comprehensive Review on Membrane Fouling: Mathematical Modelling, Prediction, Diagnosis, and Mitigation
AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Darwish, Naif; Husseini, Ghaleb (MDPI, 2021)Membrane-based separation has gained increased popularity over the past few decades, particularly reverse osmosis (RO). A major impediment to the improved performance of membrane separation processes, in general, is membrane ... -
Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment
AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (American Chemical Society, 2021)The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix ... -
Effect of High-Frequency Ultrasound on Targeted Liposomes
AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Delivering highly toxic drugs inside a safe carrier to tumors while achieving a controlled and effective drug release at the targeted sites represents an attractive approach to enhance drug efficiency while reducing its ... -
Effect of phospholipid head group on ultrasound‑triggered drug release and cellular uptake of immunoliposomes
Awad, Nahid S.; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Nature, 2023)Liposomes are the most successful nanoparticles used to date to load and deliver chemotherapeutic agents to cancer cells. They are nano-sized vesicles made up of phospholipids, and targeting moieties can be added to their ... -
Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging
Farooq, Afifa; Sabah, Shafiya; Dhou, Salam; AlSawaftah, Nour Majdi; Husseini, Ghaleb (MDPI, 2022)The field of cancer theranostics has grown rapidly in the past decade and innovative ‘biosmart’ theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current ... -
Hybrid Liposome/Metal–Organic Framework as a Promising Dual-Responsive Nanocarriers for Anticancer Drug Delivery
Karami, Abdollah; Ahmed, Ahmed H.S; Sabouni, Rana; Husseini, Ghaleb; Al Sharabati, Miral Osama Yacoub; AlSawaftah, Nour Majdi; Paul, Vinod (Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery
Karami, Abdollah; Ahmed, Ahmed H.S; Sabouni, Rana; Husseini, Ghaleb; Al Sharabati, Miral Osama Yacoub; AlSawaftah, Nour Majdi; Paul, Vinod (Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
Identification of Novel MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating the EGFR-ADAM17 Axis: An In Silico Analysis
Mukhopadhyay, Debasmita; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)Cancer patients contracting SARS-CoV-2 encounter additional challenges due to inflammatory bursts and lymphopenia, which may aggravate breast cancer prognosis. In this in-silico analysis, we identified the potential of ... -
Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis
Mukhopadhyay, Debasmita; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)In this study, we investigated the interactions between SARS-CoV-2 and miRNAs associated with lung cancer using bioinformatic approaches. A special focus was placed on TMPRSS2 and lung cancer progression pathways involving ... -
Immunoliposomes: Synthesis, Structure, and Their Potential as Drug Delivery Carriers
Sandeep, Divya; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Bentham Science, 2020)Immunoliposomes have emerged as attractive drug targeting vehicles for cancer treatment. This review presents the recent advances in the design of immunoliposomes encapsulating a variety of chemotherapeutic agents. We ... -
In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes
Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Farooq, Afifa; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable ... -
Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (Elsevier, 2023)The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the ... -
The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound
AlSawaftah, Nour Majdi; Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2022)Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable ... -
Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment
Almajed, Zeyad Mohamed; AlSawaftah, Nour Majdi; Sulieman, Hana; Husseini, Ghaleb (American Scientific Publishers, 2023-07)Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. ... -
Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review
AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (IEEE, 2021)Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. ... -
pH-Responsive Nanocarriers in Cancer Therapy
AlSawaftah, Nour Majdi; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they ... -
A Review on Membrane Biofouling: Prediction, Characterization, and Mitigation
AlSawaftah, Nour Majdi; Abuwatfa, Waad Hussein; Darwish, Naif; Husseini, Ghaleb (MDPI, 2022-12-15)Water scarcity is an increasing problem on every continent, which instigated the search for novel ways to provide clean water suitable for human use; one such way is desalination. Desalination refers to the process of ... -
A Review on Membrane Fouling Prediction Using Artificial Neural Networks (ANNs)
Abuwatfa, Waad Hussein; AlSawaftah, Nour Majdi; Darwish, Naif A.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2023-07-24)Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of ... -
State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems
Alex, Meera; AlSawaftah, Nour Majdi; Husseini, Ghaleb (MDPI, 2024-03-30)Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive ...